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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of nanoscale confocal photothermal IR micro spectroscopy n CPIR

    SBC: Anasys Instruments Corp.            Topic: 100

    Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Whole Brain Nanoscale Preservation Imaging

    SBC: Nectome Inc.            Topic: 101

    Abstract Summary Nectome will create technologies to enable whole brain nanoscale preservation and imaging a vital step towards a deep understanding of the mind and of the brainandapos s diseases Current brain processing technologies compromise between whole brain applicability or nanoscale resolution our technologies will achieve both si multaneously Similar to the way that next generation ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Protection and Treatment of the Ocular Surface Barrier

    SBC: PROTERIS BIOTECH, INC.            Topic: N

    DESCRIPTION provided by applicant Dry eye a group of disorders that affects million people over the age of in the USA today is characterized by inadequate hydration and lubrication of the ocular surface The final common pathway for all types of dry eye is disruption of the ocular surface barrier which can be assessed by quantifying uptake of water soluble dyes applied topically to the ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Single Cell Analysis via Nanoscale Tip Enhanced Laser Ablation Mass Spectrometry

    SBC: Anasys Instruments Corp.            Topic: NIGMS

    DESCRIPTION provided by applicant The goal of the proposed Phase II STTR research is to develop an imaging system capable of detecting and identifying biomolecules in cells and tissue sections with sub cellular spatial resolution The system combines an atomic force microscope AFM with mass spectrometry MS analysis and utilizes a unique tip enhanced laser ablation TELA method developed in ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Computerizing NIAAA's Best Practices for Youth Screening and Brief Intervention

    SBC: COG ANALYTICS, LLC            Topic: 400

    DESCRIPTION provided by applicant The early onset of alcohol misuse during adolescence is a widespread problem in the U S Studies have consistently documented both the short and long term adverse neurophysiological impacts and health risk behaviors associated with alcohol misuse during adolescence Given the magnitude of this problem and its myriad consequences preventing early initiation of ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a non-fibrillic amyloid-beta oligomer selective positron emission tomography imaging diagnostic for Alzheimer.

    SBC: Acumen Pharmaceuticals, Inc            Topic: NIA

    In the United States in an estimated million people suffered from Alzheimer s disease AD with as many as being undiagnosed Alzheimer s Association Three stages of AD are proposed National Institute on Aging and the Alzheimer s Association preclinical AD mild cognitive impairment MCI due to AD and dementia due to AD The preclinical stage is proposed to begin ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. TheraBracelet: The first and only wearable to instantly improve stroke hand function

    SBC: TheraBracelet, Inc.            Topic: NICHD

    Project SummaryPost stroke hand impairment is highly prevalent and severely restricts functional ability and independenceIn facteveryseconds a new stroke occursand stroke is recognized as the leading cause of long term disabilityYetthere is no assistive device to help hand function at homeevery dayduring activities of daily livingExisting devices such as hand opening orthoses are expensivee gMyomo ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Effectiveness of VBP15, a dissociative steroidal analogue, on chronic inflammation in a mouse model of multiple sclerosis

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Glucocorticoids GCandapos s such as prednisolone are used frequently to induce remission and treat multiple sclerosis MS Despite effectiveness many GC mediated detrimental side effects including osteoporosis and muscle atrophy limit long term chronic treatment of MS patients These side effects are believed to be mediated by well described glucocorticoi ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. A universal vaccine for the prevention of meningococcal meningitis in Africa

    SBC: OMVAX INC            Topic: R

    For more than years sub Saharan Africa has suffered with high rates of endemic meningococcal disease and periodic epidemic epidemics involving over cases In a low cost serogroup A polysaccharide protein conjugate vaccine MenAfriVac was introduced in the region The vaccine confers protection against serogroup A MenA disease as well as asymptomatic nasopharyngeal MenA carria ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Therapeutic inhibition of P. aeruginosa nitrogen respiration in chronic infection

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAID

    DESCRIPTION provided by applicant The goal of this STTR is to identify novel small molecule compounds targeting the nitrogen respiration pathway of Pseudomonas aeruginosa This pathway is crucial to the pathogenesis of P aeruginosa in vivo but has not yet been exploited for antimicrobial drug discovery There is a clear need for new treatments to combat P aeruginosa infections Antibiotic re ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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