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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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Develop technology platform to transform the diagnosing monitoring and treating of opioid use disordersSBC: CARI HEALTH INC Topic: NIDA
PROJECT ABSTRACT There are two big challenges to reducing the number of substance use disorders SUDs in the United States Almost of the million people who suffer from SUDs are never professionally diagnosed and never seek treatment and treatment for the small minority that does seek help is not very effective with relapse rates estimated to be between and within ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of nanoscale confocal photothermal IR micro spectroscopy n CPIRSBC: Anasys Instruments Corp. Topic: 100
Abstract This proposal will lead to a Breakthrough sub cellular D chemical composition research platform for live cells based on the new invention of sub micron confocal photothermal IR micro spectroscopy CPIR Label free sub micron chemical imaging and spectroscopy has long been sought for visualization of biomolecules and materials in complex living systems Many diseases first manifest ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: VisiSonics Corporation Topic: NIDCD
Project Summary Virtual reality games to assess and habilitate auditory spatial awareness Auditory spatial awareness ASA is the critically important skill of using sound to understand extrapersonal space and its content Both explicit sound localization and implicit environmental awareness aspects of ASA contribute to everyday listening effort fatigue and spatial attention Because heari ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Hura Imaging, Inc. Topic: 100
Project Summary Abstract X ray computed tomography CT has been increasingly used in medical diagnosis currently reaching more than million CT scans every year in the US The increasing use of CT has sparked concern over the effects of radiation dose on patients It is estimated that every CT scans will cause one future cancer i e cases of future cancers from million CT scan ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
Automated Electrophysiology Assessment of Drug induced Cardiotoxicity Based on Parallel Noninvasive Nanoelectrode ArraySBC: CYION TECHNOLOGIES LLC Topic: NIBIB
Summary Drug safety issues pose a serious challenge to the health and well being of patients The development of our innovative technology aims to address a significant gap in the in vitro assessment of drug induced cardiotoxicity which is the number one reason for withdrawals of all marketed drugs as well as the premature termination of promising drug development candidates Pressured by the eno ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: CoPlex Therapeutics, LLC Topic: NIA
ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production o ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: PEARL DIAGNOSTICS, INC. Topic: NIAID
Invasive aspergillosisIAcontinues to cause morbidity and death in medically immune compromised patientslargely because we lack sensitive diagnostic tests that are easy to use during high risk periodsWe discovered that fungal galactofuranose containing antigens are excreted in urine of infected animals and peopleusing a novel monoclonal antibodymAbIn a phase I STTRwe engineered a lateral flow devic ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: Epigen Biosciences, Inc. Topic: 101
PROJECT SUMMARY Fragile X syndromeFXSis the most common inheritable form of cognitive impairment and the leading known genetic cause of autismFXS is caused by the loss of expression of the fragile X mental retardation proteinFMRPA major challenge for FXS research is to develop treatment strategies that improve the intellectual capabilities of patientsDysregulated protein synthesis is widely accept ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
A Systematic Medical Approach to Reward Transformation SMART for Brain Health in Opioid Use DisorderSBC: Versa Integrated Solutions, Inc. Topic: 102
Summary In recent years opioid use disorder OUD and deaths due to opiate overdose e g with heroin fentanyl oxycodone in suburban and rural non minority groups has created an urgency for approaches to stem this epidemic but the rise in OUD and opiate overdose deaths has occurred in inner cities at similar rates Heroin misuse and addiction are persistent problems in African American commu ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: ODMR Technologies, Inc Topic: 101
Project Summary ODMR Technologies Inc and Prof Victor Acostaandapos s group at University of New Mexico UNM are developing a diamond chip platform capable of direct magnetic characterization of individual nanoparticles for optimized diagnostic imaging Our team is a spinoff from academic collaborations in the emerging field of diamond photonic sensors a field we helped create nearly a deca ...STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health