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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A novel anti gonorrhea immunotherapeutic

    SBC: Planet Biotechnology Incorporated            Topic: NIAID

    Antimicrobial resistance is a major public health problem worldwide Neisseria gonorrhoeae Ng the causative agent of the sexually transmitted infection gonorrhea has become multidrug resistant and has achieved superbug status Novel therapeutics against Ng are urgently needed Complement C is a key arm of innate immune defenses A mechanism used by several pathogens including Ng to esca ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Developing a highly sensitive rapid handheld vaginal swab test for the detection of Chlamydia trachomatis

    SBC: PHASE DIAGNOSTICS LLC            Topic: NIAID

    Project Summary Phase Diagnostics is aiming to create the new gold standard diagnostic for the detection of sexually transmitted infections STIs The company aims to replace lab based assays for Chlamydia trachomatis CT and expand testing accessibility to previously unreachable settings The technology combines the ease of use and very low cost of rapid point of care POC diagnostics with the ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a microperforated nanocomposite balloon for intravascular anti restenotic drug delivery

    SBC: ROSELLINI SCIENTIFIC, LLC            Topic: NHLBI

    Hemodialysis is the most common treatment for kidney failure requiring the passing of blood out of the body through a filter and back into the body Almost of hemodialysis patients undergo arteriovenous graft procedures involving the insertion of prosthetic shunts i e synthetic tubes between artery and vein particularly in the forearm With the hemodialysis patient population estimated ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment

    SBC: ZYMO RESEARCH CORP.            Topic: 101

    PROJECT SUMMARY ABSTRACT Stroke injury is a process that occurs over a long duration with pathologic changes that result in long term neurologic dysfunction For stroke there exists an important need for a strategy that can provide safe and efficacious stabilization to the hypoperfused brain and initialize long lasting endogenous neuroprotection for prevention of long term neurologic dysfunction ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Automated electrophysiological analysis of neural circuitry using a novel nano electrode array for intracellular recording of membrane potential

    SBC: CYION TECHNOLOGIES LLC            Topic: 101

    Summary Nervous systems process information by integrating the electrical activity of neurons in complex networks The alterations in the flow of electrical activity through neuronal networks of the brain play a causal role in the pathogenesis and or the appearance of symptoms of neurodegenerative and psychiatric diseases A fundamental goal of BRAIN Initiative is therefore to elucidate how the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Gold nanoparticle laser warming of cryopreserved zebrafish embryos

    SBC: NANOCOMPOSIX INC            Topic: OD

    Project Summary Abstract In the past decade laboratories around the world have produced tens of thousands of mutant transgenic and wild type zebrafish lines for a wide range of genetic and biomedical research Maintaining all of these valuable genotypes is expensive risky and beyond the capacity of even the largest stock centers Cryopreservation of zebrafish sperm eggs and embryos is vital ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Next Generation Regenerative Therapy with Pim Enhanced Cardiac Progenitor Cells

    SBC: CardioCreate, Inc.            Topic: NHLBI

    PROJECT SUMMARY Myocardial regenerative therapy is poised to revolutionize the way heart failure is treated but further improvements and enhanced products are needed to make this therapy truly safe and efficacious Our company CardioCreate Inc has pioneered the use of genetic engineering to enhance the regenerative potential of human Cardiac Progenitor Cells CPCs intended for autologous the ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Pirenzepine for CIPN

    SBC: WinSanTor, Inc.            Topic: O

    PROJECT SUMMARY Chemotherapy induced peripheral neuropathy CIPN is a debilitating complication that can arise from use of a number of chemotherapeutics and which limits both the dose and duration of cancer treatments with these agents Up to of cancer patients treated with chemotherapy describe some form of CIPN with sensory neuropathy being dominant Symptoms vary from tingling and numbne ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. SA FasL engineered human islets as a novel product for the treatment of type diabetes

    SBC: FasCure Therapeutics LLC            Topic: NIDDK

    PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Predevelopment of VV a Novel CRAC Channel Inhibitor for the Treatment of Ulcerative Colitis

    SBC: Vivreon Biosciences, LLC            Topic: R

    Vivreon Biosciences NIAID SBIR PA Project Summary Vivreon Biosciences is pleased to apply for NIAID SBIR Solicitation PA Vivreon Biosciences is an innovative life sciences company that is developing a novel small molecule Ca channel inhibitor for the treatment of ulcerative colitis UC Our lead compound VV achieves immunosuppression by an entirely new mechanism col ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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