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Aligned Nanofibrillar Scaffold Activated with HGF-mmRNA in Combination with Minced Muscle Graft for Treating Volumetric Muscle Loss (VML) InjurySBC: Fibralign Corporation Topic: DHP14009
To address the scarcity of effective treatments for volumetric muscle loss injuries, we propose a novel aligned multilumen nanofibrillar collagen scaffold loaded with Hepatocyte Growth Factor (HGF) modified messenger RNA (mmRNA) to direct functional musclSBIR Phase II 2019 Department of DefenseDefense Health Agency
SBC: EP ANALYTICS, INC.. Topic: DTRA172003
DTRA uses High Fidelity Computer Codes (HFCC) to investigate weapon effects and techniques for countering Weapons of Mass Destruction (WMD). End-to-end HFCC simulations in support of the DTRA Agent Defeat Warfighter Capability will require calculations including multiple phenomena that occur in vastly different time scales (µ-sec to hours). As DTRA becomes increasingly reliant on computational mo ...SBIR Phase II 2019 Department of DefenseDefense Threat Reduction Agency
SBC: X-Therma Inc. Topic: DHP16012
A key bottleneck to be addressed in regenerative medicine is hypothermic preservation of cells and tissues, which has been shown to extend survival of cell and tissue-based therapies by decreasing ischemic effect. However, preservation technology is aged, toxic and less effective than desired with typical cell survival post-thaw below 50% and unreliable potency. Current technology greatly hinders ...SBIR Phase II 2017 Department of DefenseDefense Health Agency
SBC: LUCID CIRCUIT, INC. Topic: DTRA162006
With the advent of high-density low-power sub-20nm technology processes and circuits with tens-of-billions of transistors, radiation-induced single-event effects present a new set of design challenges for terrestrial applications. Developing reliable single-event effect resilient microelectronics in these modern technology nodes is a resource and time-intensive endeavor that further requires valid ...SBIR Phase II 2019 Department of DefenseDefense Threat Reduction Agency
SBC: CFD RESEARCH CORPORATION Topic: DHP16001
The confluence of genetics, mobile computing, wearable sensors and computational physiology has started the revolution in personalized medicine with huge civilian and military prospects to promote health and reduce costs. The goal of this project is to develop and demonstrate a Warfighter Health Avatar (WHA): a framework and physiology based modeling tools of a warfighter body to enable assessment ...SBIR Phase II 2017 Department of DefenseDefense Health Agency
SBC: Cellmic, LLC Topic: CBD13102
We propose a high performance, cost-effective, universal Digital Assay Solutions platform with Mobile Readers, Assay Development and Calibration Software, and HIPAA-compliant cloud services for global health and defense applications. In Phase II project, we have developed the first generation product family receiving considerable interest from the assay manufacturers, government organizations and ...SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense
SBC: Advanced Life Technologies, LLC Topic: DHP12003
Surgical trainingrequires an understanding of the human body’scomplex3-dimensional anatomical structures and thespatial relationships of nerves, blood vessels and othervital structures.Learningthesespatial skills requires a lengthy training period and much practicethat usually takes placein the operatingroom while under thesupervision of a senior surgeon atgreat financial cost and potential risk ...SBIR Phase II 2017 Department of DefenseDefense Health Agency
SBC: Kalyra Pharmaceuticals, Inc. Topic: NonDOD
There has been considerable interest in the development of alternative therapies for pain management that are neither opioid nor non-steroidal anti-inflammatory drugs (NSAIDs). Kalyra Pharmaceuticals has demonstrated that acetaminophen, also known as APAPSBIR Phase II 2017 Department of DefenseDefense Health Agency
SBC: SA PHOTONICS, LLC Topic: DHA172005
In a multiple patient situation, the medics need all the help they can get. Monitoring several patients is a difficult task, and associating the vital signs data with the right patient is crucial. Providing medics with a tool to assist in this task can grSBIR Phase II 2019 Department of DefenseDefense Health Agency
SBC: CFD RESEARCH CORPORATION Topic: DHP16005
Iron deficiency is one of the most common nutritional deficiencies in the United States. Left untreated, iron stores continue to deplete, resulting in iron deficiency anemia (IDA). Women undergoing basic military training are particularly susceptible to reduced and depleted iron stores. To-date, there are no point-of-care (POC) instruments for comprehensive, accurate determination of iron status. ...SBIR Phase II 2017 Department of DefenseDefense Health Agency