Award Data

DESCRIPTION (provided by applicant): Current approaches to treat sudden sensorineural hearing loss (SSNHL) do not maintain inner ear drug concentrations within an appropriate therapeutic window for sufficient lengths of time to achieve therapeutic effect.A novel delivery system for long-term, controlled release of glucocorticoid steroids to the inner ear would constitute a dramatic improvement in ...

DESCRIPTION (provided by applicant): Dental caries, commonly known as tooth decay, is a serious health problem all over the world, and is one of the most common infectious diseases in humans. Dental plaque, a biofilm community growing on the tooth surface,can harbor organisms that cause dental caries. The mutans streptococcal group, represented by Streptococcus mutans and S. sobrinis, are the majo ...

DESCRIPTION (provided by applicant): Radikal Therapeutics (RTX) is developing a novel K+-ATP channel opener (R-801) for the prevention of radiocontrast media (CM) induced nephropathy (CIN), a devastating complication developing in gt 25% of diabetics withsignificant preexisting renal dysfunction. The high incidence of atherosclerosis in this population frequently necessitates angiographic procedur ...

DESCRIPTION (provided by applicant): We are developing a novel small molecule cytoprotective drug for the prevention of contrast-induced nephropathy (CIN) following intravenous radiocontrast media (CM) injection. CIN is mediated principally by CM-induced vasoconstriction of the afferent renal arteriololes, resulting in antidiuresis and severely compromised renal blood flow. The consequent renal is ...

DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a cell-coated device for the treatment of acute liver failure. The device harnesses mesenchymal stem cell secretions to provide combined anti-inflammatory and regenerativesupport. The project specific aims are: (1) Positron emission tomography (PET)-guided optimization of cellular coatings; and (2) To perform a dos ...

DESCRIPTION (provided by applicant): Rechargeable lithium-ion batteries (LIB) are providing power for an increasing range of portable medical devices. With their light weight and higher voltages, device capabilities have improved within acceptable weight limits for portability. However, the batteries' issues with reliability, safety, service life and operating temperature range, have limited ...

DESCRIPTION (provided by applicant): In the project, We propose to develop compliant restraining devices for mice during imaging applications. Mice are used in biomedical research in order to understand the human body, determine the effects of diseases, and develop treatments for diseases in humans. Imaging immune cells and cancer cells in live mice have been well established for biomedical resear ...

DESCRIPTION (provided by applicant): Giner, Inc. proposes a portable, inexpensive, and rapid-response monitor for arsenic speciation in urine. Arsenic species excreted in urine are reflective of human exposure to toxic arsenic, and therefore this sensor will be a valuable biomonitoring tool in medical diagnostics and epidemiological studies by allowing determination of arsenic exposure faster and ...

DESCRIPTION (provided by applicant): Development of a Novel Aerosol Mass Spectrometric Technology for Rapid and Sensitive Biomonitoring of Environmental Toxicants Name, address, and telephone number of the Principal Investigator: Dr. Manjula Canagaratna,Aerodyne Research, Inc., 45 Manning Rd., Billerica, MA 01821-3976, 1-978-663-9500 ext. 285 Names of other key personnel: Prof. Qi Zhang, Prof. F ...

DESCRIPTION (provided by applicant): AcoustiMap We will develop a navigation assistance device for blind users. It will consist of an auditory display that places sound sources in three-dimensional space around the user, a Global Positioning System (GPS) unit with a map database, and a Dead Reckoning Module to provide precise location and orientation in three dimensions. All three components use p ...