Award Data

ABSTRACTThis SBIR Phase I proposal requests $178,410.00 (total cost) support for Advantage Silver Dental Arrest, LLC. to develop and assess the technical and scientific feasibility of High Fluoride Toothpaste that also contains Povidone Iodine as a commercial product to arrest dental caries. This proposal responds to the NIDCR Preclinical Research topic: “Preclinical research and development act ...

Proposal Summary There is increasing appreciation of a syndrome in which patients female patients, present with chest pain due to myocardial ischemia and have a normal or near normal coronary angiogram. Termed coronary microvascular dysfunction (MVD) this disorder is not benign with cardiovascular event rates similar to those with established coronary artery disease. Clinical tools are therefore n ...

The capabilities of native mass spectrometry have improved dramatically in recent years due to advances in instrument speed, resolution, mass accuracy, and ion optics designed specifically to handle large protein complexes. Despite these advances, the depth of characterization achievable by native mass spectrometry is still limited due to inefficient dissociation and fragmentation of large protein ...

Project Summary Although potent antithrombotic drugs are available, all inadvertently target vital hemostatic mechanisms, resulting in dose-limiting hemorrhagic toxicity that restricts their use. Due to a lack of safe thromboprophylaxis, thrombotic/thromboembolic blood vessel occlusions and vascular device failures remain among the leading causes of death and severe chronic disability in the U.S. ...

Each year, over 6 million fractures are treated in the United States at a cost in excess of $13 billion. Between 5-8% of these fractures experience complications, particularly in the steadily increasing population with osteoporosis. By providing better fixation in osteoporotic bone, locked plating technology rapidly transformed fracture treatment with bone plates. Locked plating has captured 83% o ...

Abstract The emerging interdisciplinary research field of Regenerative Rehabilitation is based on recent evidence that post-operative rehabilitation is as important as surgical technique to achieve optimal functional restoration following orthopedic injuries. Despite this recognition, current rehabilitation protocols remain primarily based on qualitative prior experience or preferences and lack pa ...

PROJECT SUMMARY/ABSTRACT A substantial body of evidence supports the use of behavioral parenting strategies in reducing child disruptive behavior disorders. Empirically supported behavioral parent training protocols exist to teach parents how to employ these effective parenting strategies, but many obstacles interfere with parentsandapos; access to these supports and their regular use of effective ...

PROJECT SUMMARY Hemoglobin (Hb) disorders are among the worldandapos;s most common monogenic diseases. Nearly 7% of the world’s population carry Hb gene variants. Sickle cell disease (SCD) arises when Hb mutations are inherited homozygously (HbSS) or paired with another β-globin gene mutation. Globally, an estimated 400,000 babies are born annually with SCD, and 70%-75% are in sub-Saharan Afric ...

AbstractLife sciences research and other critical bioanalytical applications would strongly benefit from faster and higher resolution high performance liquid chromatographic (HPLC) separations of larger molecules including proteins, peptides, glycopeptides, and glycans. Proteins therapeutics are complex molecules, susceptible to intended or unintended alterations of composition and conformation. M ...

HER2+ breast cancer (HER2+ BC) is an aggressive type of breast cancer that claims the lives of over 120,000 women annually worldwide. Current treatments for HER2+ BC rely on chemotherapy in combination with trastuzumab, pertuzumab, and trastuzumab-emtansine (TD-M1), which target the HER2 receptor on cancer cells. While initially responsive to these treatments, HER2+ breast cancer eventually progre ...