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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Advanced retinal image analysis for AMD screening

    SBC: EYENUK, INC.            Topic: N

    DESCRIPTION provided by applicant In this grant application we propose to develop a screening tool for Age related macular degeneration AMD the single largest cause for legal blindness among aged Americans A robust screening test that can be performed by a primary care physician or an optometrist who can then refer the patient to an ophthalmologist will be a useful first step in casting ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Advanced Production of High Purity Radioisotopes for Nuclear Medicine

    SBC: Purist Inc            Topic: 400

    Project Summary Abstract ! The availability of reactor produced radioisotopes relies significantly on aging foreign resourcesleading to an uncertainty in the future supply of these lifesaving radioactive ingredientsThe long term goal of this effort is development of a platform technology that can be implemented in existing research reactor infrastructure nationwide for local medical grade radioiso ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Advancing a novel potent Zika virus specific nucleoside analog to the clinic

    SBC: Riboscience LLC            Topic: R

    Our goal is to leverage our exciting SBIR Phase equivalent research results into a novel nucleoside based treatment for Zika virus ZIKV that can be used for prevention or treatment of ZIKV infection Our lead molecule RBS is the first potent and specific inhibitor of ZIKV replication EC micromolar CC andgt micromolar and that is suitable for the development of both ora ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Advancing Allosteric CaMKII Inhibitors to Treat Multiple Novel Pathways in Diabetes

    SBC: ALLOSTEROS THERAPEUTICS, INC.            Topic: 200

    Type diabetes mellitus has become a worldwide epidemic with significant human and economic burdens Diabetic patients are particularly at risk of mortality from myocardial infarction and it is therefore important that glucose lowering is achieved by drugs that do not further compromise the heart Evidence now supports Ca calmodulin dependent protein kinase II CaMKII a mediator Ca signalin ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Advancing a novel potent double anti-HCV nucleoside analog combination treatment for the OUD population to the clinic

    SBC: Riboscience LLC            Topic: NIDA

    Our goal is to develop an ultra short curative regimen for hepatitis C virusHCVinfection in OUD patientsHCV is a major co morbidity of many OUD patientsTreating their HCV reduces their subsequent IV drug useWhile currently available regimens can cure HCV in most patients inweekslonger in patients with advanced liver disease or drug resistance mutations that are more frequent in OUD patientswhen th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Advancing a novel potent Zika virus specific nucleoside analog to the clinic

    SBC: Riboscience LLC            Topic: R

    Our goal is to leverage our excitingSBIR Phaseequivalentresearch results into a novel nucleoside based treatment for Zika virusZIKVthat can be used for prevention or treatment of ZIKV infectionOur lead moleculeRBSis the first potent and specific inhibitor of ZIKV replicationECmicromolarCCandgtmicromolarand that is suitable for the development of both oral and intravenous dosage formsRBSis a prodru ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Advancing Protein Engineering Using Artificial Intelligence and the ProtaBank Mutation Database

    SBC: PROTABIT LLC            Topic: 400

    PROJECT SUMMARY Therapeutic antibodiesspecialized enzymes for drug manufacturingsmall molecule drug screening agentsand other proteins have been instrumental in advancing biotechnology and medicineProtein therapeutics alone represents a rapidly growing $billion market with broad applications in the treatment of cancerinflammatory and metabolic diseasesand numerous other disordersMost of the antibo ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Aerosol Delivery of Surfactant for ARDS

    SBC: KAER BIOTHERAPEUTICS CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Acute respiratory distress syndrome ARDS is of multifactorial etiology and afflicts to Americans each year and of all ventilated patients Despite sophisticated intensive care the mortality rate ranges between and with a mean of Patients with ARDS have impaired surfactant function and continued inflammation induced metabolism of ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Aerosol Delivery of Surfactant for ARDS

    SBC: KAER BIOTHERAPEUTICS CORPORATION            Topic: NHLBI

    Acute respiratory distress syndromeARDSafflicts aboutAmericans each yearThe pathology consists of rapid onset of respiratory symptoms including radiographic bilateral opacities and pulmonary edemaThe primary risk factors for the development of ARDS are pneumoniaaspirationmajor traumasepsisand inhalation injuryDespite the adoption of lung protective ventilationthe mortality rate remains aboutCommon ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. A fast, scalable, cost-effective, single-stranded library protocol for cell-free DNA

    SBC: Claret Bioscience LLC            Topic: 102

    Project Summary Liquid biopsy is a potentially powerfulnon invasive approach for detectingclassifying and monitoring tumors by capturing cell free DNA molecules found circulating in blood and other bodily fluidsAny next generation sequencingNGSbased approach requires an efficient protocol for converting cell free DNA into a sequencing libraryNearly all currently available NGS library preparation m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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