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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

Displaying 81 - 90 of 8312 results
  1. Realistic Adaptive Immersive Learning System (RAILS) for HAZMAT Site MonitoringCharacterization and Remediation Training

    SBC: Spectral Labs Incorporated            Topic: 142

    Project SummaryThe work proposed aims to develop an immersive videogame-based training program to train HAZMAT workers specifically involved in the emergency response, site characterization, waste removal, and site remediation at the extensively contaminated sites on the National Priorities List. Specific training will be designed to meet the mandates of 29 CFR 1910.120 for HAZWOPER training requi ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  2. Engineering a unique antibody for patients with RA

    SBC: Abwiz Bio, Inc.            Topic: NIAID

    RA is one of the most common chronic autoimmune disorders that can lead to complete joint destruction and severe disability if untreated. There is no cure for RA and up to 50% of RA patients do not respond to anti-TNF therapies as circulating Th-17/IL-17 levels are highly elevated subsequent to TNF blockade. For this subset of RA patients, disruption of a novel pathway that impairs the synergy bet ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  3. A next-generation meningococcal serogroup B vaccine with improved effectiveness for all age groups

    SBC: Omvax, Inc.            Topic: NIAID

    AbstractNeisseria meningitidis is a major cause of meningitis and septicemia. Serogroup B (MenB) strains account for most cases of invasive disease in infants and teenagers and nearly all U.S. college outbreaks. The MenB capsule cross-reacts with host antigens, which precluded development of a capsular-based MenB conjugate vaccine. Two manufacturers developed MenB vaccines that target protein anti ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  4. Vasodilation Needle for Trans-Radial Access

    SBC: 3dt Holdings, LLC            Topic: NHLBI

    SUMMARY The number of percutaneous arterial access procedures using the transradial access (TRA) approach is growing rapidly in the US. Interventionalists are adopting the TRA technique due to lower risks associated with bleeding and no need for active vascular closure devices. TRA catheterization also satisfies patients because of increased comfort and mobility. Same-day discharge is generally po ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

    SBC: Amino Company LLC, The            Topic: 300

    7. Project Summary/Abstract Bariatric surgery has become a common treatment for severe obesity. While this results in the desired loss of fat mass, muscle mass is also lost with implications for post-surgical health benefits. It is our overarching premise that consumption of our essential amino acid (EAA)-based nutritional formulation following bariatric surgery will preserve muscle mass by stimul ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Development of TP-352 for the Treatment of Pediatric Non-alcoholic Steatohepatitis

    SBC: Thetis Pharmaceuticals LLC            Topic: 300

    ABSTRACTNon-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases related to metabolic syndrome that are characterized by steatosis, the accumulation of fat within the liver. Non-alcoholic steatohepatitis (NASH), the most aggressive NAFLD subtype, refers to the presence of inflammation and necrosis in a background of steatosis, and is associated with hepatic fibrosis. NASH is a se ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  7. A Laparoscopic Grasping Instrument for Robust and Atraumatic Tissue Manipulation in Minimally-Invasive Gastrointestinal Surgery

    SBC: Theranova LLC            Topic: R

    Abstract With up to 4.8 million procedures annually in the U.S., laparoscopy has rapidly become the surgical standard for a wide range of procedures. Compared to open procedures, laparoscopic approaches reduce muscle damage, blood loss, post-operative pain, complication rates, and length of hospital stay. However, laparoscopy has unique technique-specific limitations and complications, so the perc ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. HBI-002 to Prevent Anthracycline-Related Cardiotoxicity

    SBC: Hillhurst Biopharmaceuticals, Inc.            Topic: NHLBI

    PROJECT SUMMARY There is an urgent need for the development of approaches to prevent cardiotoxicity in cancer patients being treated with anthracyclines, an important class of drugs in the treatment of cancer (e.g. doxorubicin). Anthracycline treatment-related cardiotoxicity is a major clinical problem that severely impacts patient care and also limits dose and usage. More than a quarter of patien ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Algorithms for Reducing Radiation Dose of CT Perfusion

    SBC: Hura Imaging, Inc.            Topic: NIBIB

    Project Summary/Abstract X-ray computed tomography (CT) has been increasingly used in medical diagnosis, currently reaching more than 100 million CT scans every year in the US. The increasing use of CT has sparked concern over the effects of radiation dose on patients. It is estimated that every 2000 CT scans will cause one future cancer, i.e., 50,000 cases of future cancers from 100 million CT sc ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  10. HBI-002 to Treat Ulcerative Colitis

    SBC: Hillhurst Biopharmaceuticals, Inc.            Topic: 300

    PROJECT SUMMARY There is an urgent need for the development of new approaches to treat patients suffering from Ulcerative Colitis (UC), which is estimated to impact approximately one million adults in the United States, leading to morbidity, heightened risk of cancer, and mortality. In multiple preclinical studies, we and others have defined the therapeutic potential of low-dose exogenous carbon m ...

    STTR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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