Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Plant-derived molecular condom as an on-demand nonhormonal female contraceptive

    SBC: YourChoice Therapeutics, Inc.            Topic: NICHD

    Consumer behavior throughout the world points to a high level of dissatisfaction with currently available contraceptive methodsAlmost a third of American women discontinue using hormonal methods of birth control within the first yearwhileof men discontinue using condoms within the same timelineConsumers are not satisfied with either the continual methodshormonalor the on demand optionsuch as condo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a Next Generation Visual Performance Assessment System for Rodents

    SBC: AFASCI, INC.            Topic: NEI

    PROJECT SUMMARY TitleDevelopment of a Next Generation Visual Performance Assessment System for Rodents Visual behavior abnormalities not only link directly to the retinal pathology and visual pathway disordersbut also associate with many neurodegenerative brain conditionsparticularly with Alzheimer s diseaseParkinson s diseaseand traumatic brain injuryThe optomotor reflexOMRconsists of innaterefle ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Development of Nicotine Vapor Inhalation Chambers for Rodent Self-Administration

    SBC: LA JOLLA ALCOHOL RESEARCH INC            Topic: NIDA

    Project Summary This Phase II SBIR project will developoptimizetestcommercializeand take to market an inhalation chamber that mimics the e cigarette technology being used by human usersand being popularized by ecigarette manufacturers and advertisersE cigarette use and abuse is a major public health concernbut little is known about the biology underlying e cigarette use and negative health impact ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Two-in-One Approach to Administer Surfactant and Provide Airway Support to VLBW Infants

    SBC: BB MEDICAL SURGICAL, INC            Topic: NICHD

    PROJECT SUMMARYABSTRACT Every yearvery low birth weightVLBWandltginfants are born in the U SThe use of surfactant dramatically decreases morbidity and mortality due to respiratory distress syndromeRDSin VLBW infantsCurrent standards for surfactant administration require the infant to be intubatedso that surfactant can be delivered to the trachea and lungsIntubating a VLBW infant is challenging and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Eliminating Interference from Autofluorescence in Flow Cytometry

    SBC: Kinetic River Corp.            Topic: 400

    SUMMARY Flow cytometry is a powerful cell analysis toolproviding information on cell countshapesizeDNA contentredox statemembrane permeabilityand surface receptorsamong other featuresIt can be used on both live and fixed cellsand can be used to non destructively sort cells based on these characteristicsFlow cytometry has utility in research and clinical fields as diverse and important as tumor bio ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Stabilization of the RNA Complement of Enveloped Viruses: Beta Testing and Manufacturing Scale-up of a Novel Filter Paper Product for the Field Collection of Dried Blood Spots

    SBC: GenTegra LLC            Topic: NIAID

    AbstractInfilter paper based sample collection with Guthrie Cards revolutionized blood based screening of small molecule biomarkers of birth defectvia the collection of heal stick blood directly onto filter paperto form a dried blood spotDBSIn theandapos sGuthrie CardWhatmanDBS sample collection was extendedby this Team and many othersto DNA biomarkers and to analysis of blood borne bacteria and D ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of MTX-211 for the Treatment of KRAS Mutant Colorectal Cancer

    SBC: Mekanistic Therapeutics, LLC            Topic: 102

    PROJECT SUMMARY Mekanistic Therapeutics seeks to designdiscoverand develop anti cancer agents that selectively inhibit multiple oncogenic pathwaysIts lead agent MTXwas discovered in collaboration with the Leopold laboratory at University of MichiganThe overall objective of this project is to expediently advance MTXinto development for the treatment of KRAS mutant colorectal cancerCRCEvery year and ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Multiplexing methods to reduce sequencing costs.

    SBC: Coral Genomics, Inc.            Topic: 172

    Project Summary As the capacity of next generation sequencing machines has increasedthe marginal cost of shallow sequencing has become much higher than that of deep sequencingFor the development of novel protocolsquality checkingand targeted clinical sequencingsequencing demand is often far less than an entire sequencing runThis issue can be resolved if a user can find a partner performing a high ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Novel Intra-aneurysmal Rapid Occlusion Device

    SBC: NEUROGAMI MEDICAL, INC.            Topic: NINDS

    PROJECT SUMMARY The long term objective of this research program is to improve the care of patients harboring unruptured as well as ruptured intracranial aneurysmsUnruptured aneurysms are present in approximatelytomillion AmericansAn estimatedof those aneurysms will rupture annually resulting in aboutfatalityThe most modern techniques for aneurysm treatment include minimally invasivenonsurgical ap ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A therapeutic vaccine for chronic hepatitis B

    SBC: VLP BIOTECH, INC.            Topic: R

    Project Summary AbstractAlthough a safe and efficacious preventative vaccine for HBV has been available foryearsit is not effective against chronic infectionThe primary cause of chronic HBVCHBand the greatest impediment to developing a therapeutic vaccine is the direct and indirect effects of immune toleranceprimarily of CDT cellsto HBV antigensThe resulting defective CDCDT cell responsepoor cytok ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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