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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Small molecule inhibitors of group II introns for treatment of fungal infections

    SBC: New England Discovery Partners, LLC            Topic: NIAID

    DESCRIPTION provided by applicant This project will result in the development of potent new inhibitors for a novel enzyme target that is specific to the metabolism of fungi and yeast the group II self splicing intron This structurally complex and highly conserved ribozyme plays a key role in RNA processing and metabolic function of lower eukaryotes but it is not present in humans and other v ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Arf6 inhibitors for the treatment of uveal melanoma

    SBC: NAVIGEN, INC.            Topic: 102

    DESCRIPTION provided by applicant Activating mutations in G proteins are the drivers of oncogenesis in numerous cancers Therefore identifying drugs that block the signaling pathways controlled by these mutations could have enormous therapeutic consequences Uveal melanoma is a prototypical G driven cancer in which about of tumors have activating mutations in one of two G encoding genes ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Targeted drug delivery to tumor microenvironment

    SBC: SIBTECH, INC.            Topic: 102

    DESCRIPTION provided by applicant The goal of this project is to test the feasibility of targeted delivery of andquot re programmingandquot liposomal drugs to tumor associated macrophages TAMs TAMs are the major component of tumor microenvironment that generally supports tumor growth and interferes with anti tumor therapy These effects are significantly mediated by about of TAMs that ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. Profiling Circulating miRNA Without PCR for Early Detection of Pancreatic Cancer

    SBC: VAJRA INSTRUMENTS, INC.            Topic: 102

    DESCRIPTION provided by applicant Pancreatic cancer PaC has a poor prognosis in most cases due to the lack of early detection owing to its nonspecific asymptomatic nature An effective inexpensive screening tool is needed for early diagnosis within years of tumor initiation It is well accepted that genomic instability is a hallmark of cancer Recent research indicates that less than ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a heterologous bio-production system for the clinically important anti-cancer natural product compound ET-743

    SBC: ALLUVIUM BIOSCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant Ecteinascidin ET is a tetrahydroisoquinolone natural product that displays potent anti cancer activity Isolated in very low yields from the marine colonial tunicate Ecteinascidia turbinata ET has been developed by PharmaMar as a cancer chemotherapeutic agent currently marketed in Europe as trabectedin Yondelis r for the treatment of soft tiss ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Targeted Intraceptor Nanoparticle for Macular Degeneration

    SBC: IVEENA DELIVERY SYSTEMS, LLC            Topic: N

    DESCRIPTION provided by applicant Age related macular degeneration AMD is a leading cause of blindness in United States and many other industrialized nations There are two types of AMD the andquot dryandquot and andquot wetandquot forms Dry AMD is a chronic disease that usually causes variable degree of visual impairment In contrast in wet AMD which affects of AMD patients t ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. A multi-analyte device for air quality monitoring

    SBC: TF HEALTH CORPORATION            Topic: NIEHS

    DESCRIPTION provided by applicant Air quality affects the health and well being of each of us especially those with chronic respiratory diseases Acute exposure to fatal levels of hazard materials causes millions of accidents every year and unnoticed long term exposure to lower levels of chemicals affect far more people Various technologies have been developed to monitor air quality but no ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS-2 Dependent Insulin Signaling Cascade.

    SBC: HOUSEY PHARMACEUTICAL RESEARCH LAB            Topic: 200

    DESCRIPTION provided by applicant This is a Phase I SBIR Application entitled andquot Isolation and Characterization of Low Molecular Weight Compounds Derived from Plant Extracts that Activate the IRS Dependent Insulin Signaling Cascade andquot Diabetes is a growing and significant global health concern Insulin Receptor Substrate IRS is a critical component in the insulin mediated s ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. A new approach to fast, diagnostic-quality, intraoperative microscopic examination

    SBC: Applikate Technologies LLC            Topic: NIBIB

    DESCRIPTION provided by applicant The goal of this Phase I SBIR proposal from Applikate Technologies LLC is to validate and optimize RapidView a novel approach to intraoperative microscopic analysis of excised tissue Currently pathologists analyze flash frozen tissue sections to provide immediate histological evaluation of surgical excisions for million operations per year in the United ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Treating Acute Lung Injury via Cytokine Signaling Blockade

    SBC: NAVIGEN, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Acute lung injury ALI and acute respiratory distress syndrome ARDS result from a common pathogenic process pulmonary injury or infection triggers an overwhelming inflammatory response andquot cytokine stormandquot that results in increased endothelial and epithelial permeability and efflux of inflammatory cells protein and water from the vascular syst ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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