Award Data

Significance/Goal. Although immune checkpoint inhibitors (ICIs) have shown impressive outcomes in melanoma patients, the majority of patients fail to respond, mainly due to the absence of tumor-infiltrating T cells. In order to boost the anti-tumor T cell repertoire, we have developed a novel immuno-nanotherapeutic, called “Augmenting Immune Response and Inhibiting Suppressive Environment of tum ...

Approximately 12% of women have a false-positive result after one mammogram, and 60% have a false positive after ten yearly mammograms - resulting in the need for secondary screenings. The cost of unnecessary secondary screenings, often due to the inability to differentiate between healthy and unhealthy tissue with the desired accuracy, has been calculated to be $4 billion per year. Increasing the ...

Summary/Abstract People with opioid use disorder (OUD) experience aversive opioid withdrawal symptoms (OWS) including nausea, diarrhea, vomiting, and anxiety, which emerge when blood opioid levels wane. These symptoms perpetuate unprescribed opioid use and accompanying morbidity and mortality, costing society nearly $80 billion per year. Withdrawal symptoms also emerge upon initiation of OUD pharm ...

Project Summary According to the Centers for Disease Control (CDC), synthetic opioids are currently the most common cause of overdose death in the U.S, while heroin and prescription opioid deaths have decreased significantly since 2017. Despite the widespread availability of naloxone, deaths from fentanyl and fentanyl analogues (F/FA) continue to rise in parallel with increasing reports of F/FA re ...

This Phase I SBIR project develops and evaluates the Person-Centered Approach to Diabetes Self-Management (PCADS) system, a hardware/software prototype to improve Type 2 diabetes self-management for individuals with intellectual and developmental disabilities (IDD). Project activities build on a promising pilot study conducted with the Oregon Office on Disability and Health (OOHD) that serves as t ...

AbstractPost-operative bleeding remains the major complication of transurethral and open prostatic surgical procedures. Prolonged bleeding from these procedures causes delayed healing and longer hospitalization which significantly increases the cost of patient care. Moreover, prolonged urethral catheterization due to significant post-operative hematuria is one of the major causes of discomfort and ...

Emergent Healthcare Solutions proposes to research the feasibility of a dynamic cloud-based incident Intelligence System called Emergent Cloud. Emergent Cloud is an application service providing firefighters and Emergency Medical Technicians access to an interactive incident roadmap and real-time workflow and record keeping. The general aim of the proposed project is to revolutionize the user expe ...

This project develops the Person-Centered Oral Health Care System (PCOHS), a model that facilitates both enhanced self-managed oral health care while also providing a platform for training, coaching, and coordinated care for individuals with intellectual and developmental disabilities (IDD) and their support teams. Through the platform, dental practitioners can customize oral health supports that ...

ABSTRACT This SBIR Phase I proposal requests $162,464 support for Advantage Silver Dental Arrest, LLC. to develop and assess the technical and scientific feasibility of Silicon Dioxide Encapsulated Silver Diamine Fluoride (E- SDF) as a commercial product to arrest dental caries. The goal is to regulate the dosage of SDF to caries lesions by way of encapsulating SDF in pH-sensitive silicon dioxide ...

AbstractYouth homelessness is a significant and growing public health problem, with unhoused youth being particularly vulnerable to negative health outcomes. Connecting these youth to services improves outcomes, and many communities are making efforts to do so. Youth homelessness is a complex challenge. Some communities are addressing it by a collective impact approach which relies on five key ele ...