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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Cartilage-Cartilage Adhesion by Photopolymerization

    SBC: Synthasome, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): We have recently developed a new technology called tissue-initiated photopolymerization, which permits direct covalent integration of a polymer into collagen, that has been shown to mechanically stabilize the hydrogel-cartilage interaction. Furthermore, the technique we have developed, allows in situ hydrogel formation to occur without exogenous photoinitiator, ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. PNA for Stroke

    SBC: SYNZYME TECHNOLOGIES LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Stroke is the 3rd leading cause of death in the U.S. and is also a leading cause of severe, long-term disability. The total cost of stroke to the United States is estimated at about $43 billion per year. The only FDA-approved treatment for acute ischemic stroke is recombinant tissue plasminogen activator (rt- PA). However, the therapeutic window of rt-PA is on ...

    SBIR Phase II 2005 Department of Health and Human Services
  3. Global Gene Functional Analysis with siRNA Libraries

    SBC: System Biosciences, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The greatest challenge of the post genomic era is to uncover functions of every individual human gene. Development of novel high throughput functional genomics tools are critical for genome-wide discovery and validation of drug targets, and to open avenues for newer concepts in drug therapy and diagnostics of complex human diseases. The recent introduction of ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. HUMAN FACTORS ANALYSIS IN VIRTUAL REALITY FOR BURN VICTIMS

    SBC: Virtual Reality Medical Center, The            Topic: N/A

    N/A

    SBIR Phase II 2005 Department of Health and Human Services
  5. Development of an Ergonomic Manual Wheelchair Pushrim

    SBC: THREE RIVERS HOLDINGS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Standard wheelchair handrims are too small to provide an ergonomic grip for the hand, there is no place to rest the thumb, and there are not separate propulsion and braking surfaces. As a result, over 60% of wheelchair users grab their tire when propelling their chair. The poor fit to the hand also makes propelling less efficient and more harmful to the arms a ...

    SBIR Phase II 2005 Department of Health and Human Services
  6. Inverted SQUID microscope for neuroscience research

    SBC: Tristan Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): We will develop a prototype inverted SQUID (Superconducting Quantum Interference Device) microscope for neuroscience research. The signal levels are expected to be much weaker (100-500 ftrms, ft = 10/-15 Tesla) than signals in the area of non-destructive evaluation (> 1 pT, pT= 10/-12 Tesla) where SQUID microscopes have been used previously. Therefore, in Ph ...

    SBIR Phase II 2005 Department of Health and Human Services
  7. CMV Immunotherapeutic Vaccine

    SBC: VICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Vical Inc. of San Diego, Ca. is the largest GMP manufacturer of plasmid DNA for vaccine clinical trials in the world. We have manufactured GMP plasmid DNA vaccines that are being used or entering clinical trials for HIV (in the US and China), malaria (up to 9 plasmids), Ebola, WNV, and SARS. Vical has undertaken an internal Product Development Program that focu ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. X-ray Phase Microscopy of Biological Samples in 3D

    SBC: Xradia            Topic: N/A

    DESCRIPTION (provided by applicant): In-situ high-resolution 3D imaging of cell or tissue samples offers an important capability to biomedical researchers. It is particularly valuable when the observation can be made at a resolution approaching molecular level with samples that have undergone little morphological or functional change from its natural living state (e.g. cryo preserved), and in comb ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. Biodegradable Sealant for Biopsy Tract in Soft Tissue

    SBC: BIOPSY SCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Percutaneous Transthoracic Lung Biopsy using a Fine Needle Aspiration (FNA) biopsy is a common method of determining if a lung nodule is benign or malignant. Using imaging guidance {CT, fluoroscopy, ultrasound or bronchoscopy) a sharp needle is advanced into a suspicious area and cells are aspirated into the needle. These cells are then evaluated under a m ...

    SBIR Phase II 2005 Department of Health and Human Services
  10. Encapsulated Porcine Islets into Rhesus Macaques

    SBC: MICROISLET, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The concept of islet allotransplantation as a treatment for Type I Diabetes has been demonstrated as feasible by the pioneering work done in Edmonton, Miami, Minneapolis, Philadelphia and other sites during the last five years. However, there still exists a considerable shortage of tissue for transplantation. The focus of Microlslet, Inc is to meet the increase ...

    SBIR Phase II 2005 Department of Health and Human Services

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