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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. HUMAN NEURAL STEM CELLS TARGET GENE THERAPY-BRAIN TUMORS

    SBC: LAYTON BIOSCIENCE, INC.            Topic: N/A

    Neural stem cells (NSCs) show a remarkable ability to migrate throughout the CNS, intermingle with host cells, and express foreign transgenes following transplantation. Intriguingly, this inherent migratory property of NSCs emulates the migratory pattern of some brain tumors, such as gliomas, characterized by invasive single cell migration. Potentially, the migratory properties of NSCs can be harn ...

    SBIR Phase II 2001 Department of Health and Human Services
  2. Development of BabySQUID for Neonatal Brain Assessment

    SBC: LAYTON BIOSCIENCE, INC.            Topic: N/A

    N/A

    SBIR Phase II 2001 Department of Health and Human Services
  3. Rapid, Automated, Multi-Sample Purification of RNA

    SBC: MACCONNELL RESEARCH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): In Phase II, we will develop a fully automatic, high-throughput, low-cost, multi-sample mRNA purification instrument and disposable sample cassettes. Unlike any other process currently available for mRNA purification, this instrument uses a derivative of the electrophoretic separation technology that was previously developed by our c ...

    SBIR Phase II 2001 Department of Health and Human Services
  4. Ultra-sensitive assays using SQUID magnetic sensors

    SBC: MAGNESENSORS, INC.            Topic: N/A

    The goal of the proposed SBIR Phase 2 program is to demonstrate a new magnetic detection platform technology in a next generation instrument that is capable of performing ultra-sensitive homogeneous assays for a wide range of analytes. The novel magnetic detection system will take advantage of major advances in high-temperature (high-Tc) SQUID sensors that enables the quantitative measurements of ...

    SBIR Phase II 2001 Department of Health and Human Services
  5. AIRWAY PERFUSION ASSISTED LIQUID VENTILATOR

    SBC: MALLARD MEDICAL CO., INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We have developed and patented (U.S. Pat No. 5,706,830) a new type of closed circuit perfluorocarbon (PFC) liquid ventilator with enhanced capabilities for gas exchange and exudates clearance from the lungs. This system has potential application to rescue of patients in acute respiratory failure and treatment of cystic fibrosis. ...

    STTR Phase II 2001 Department of Health and Human Services
  6. TTL- A NEW CLASS OF ORAL TNF-ALPHA SYNTHESIS INHIBITORS

    SBC: NEREUS PHARMACEUTICALS            Topic: N/A

    N/A

    SBIR Phase II 2001 Department of Health and Human Services
  7. NEONATAL OPTICAL NON-INVASIVE BRAIN OXYGENATION MONITOR

    SBC: NEUROBEHAVIORAL SYSTEMS INC            Topic: N/A

    N/A

    SBIR Phase II 2001 Department of Health and Human Services
  8. Novel Non-Peptide Antagonists of the GnRH Receptor

    SBC: Neurocrine Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Prostate cancer, breast cancer, endometriosis and uterine fibroids are fairly common and serious diseases in men and women. Their etiology is not fully understood, but all can be treated by removal of endogenous gonadal steroid hormones, testosterone and estrogen. This has led to the discovery of several successful pharmace ...

    SBIR Phase II 2001 Department of Health and Human Services
  9. HLA TYPING USING OLIGONUCLEOTIDE ARRAYS

    SBC: One Lambda, Inc.            Topic: N/A

    APPLICANT?S DESCRIPTION: The objective of this proposal is to develop a commercial HLA (human leucocyte antigen) typing system using a microsphere-based DNA probe array. Characterization of HLA gene at DNA level has become a crucial tool in identifying HLA compatible donor-recipient pairs for successful human organ/marrow transplantation. Here, we describe an advanced yet tangible method of HLA ty ...

    SBIR Phase II 2001 Department of Health and Human Services
  10. FBPase inhibitors for glycemic control in diabetes

    SBC: ONTOGEN CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 2001 Department of Health and Human Services

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