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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: ALEXANDER BIODISCOVERIES Topic: NIAID
Influenza is a continuing worldwide public health threat, with seasonal activity that is not adequately controlled by the yearly vaccine program. The severity of this problem is likely to increase with emergence of new influenza virus strains in the human population, and this situation is made even more complex by the COVID-19 pandemic. Both COVID-19 and the 2009 H1N1 influenza pandemics are remin ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: Venomyx, Inc. Topic: 400
PROJECT SUMMARY Snakebite constitutes one of the largest and most tenacious public health issues on a global scale. Every year, up to 5 million people will suffer snakebite envenomation, causing approximately 125,000 deaths and 400,000 left with permanent physical disability. Nearly 8,000 snakebites occur in the United States each year. The regions most affected are in Asia, Africa, Latin America, ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: UNDERDOG PHARMACEUTICALS, INC. Topic: NIA
Project Summary/Abstract Underdog Pharmaceuticals, Inc. (UDP), in collaboration with the SENS Research Foundation (SRF), aims to demonstrate that 7-ketocholesterol (7KC) is elevated in red blood cells (RBCs) in Atherosclerosis and Alzheimer’s disease. 7KC is primarily created by non-enzymatic oxidation of cholesterol. With only a few exceptions, human tissues lack the ability to metabolize or ex ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: Acrigen Biosciences, Inc. Topic: 100
Abstract In the nearly 20 years since the groundbreaking sequencing of the human genome, the potential for precision genetic medicine has still not been realized. Advances in sequencing have vastly increased our ability to screen patients (including parents and fetuses) for genetic abnormalities, dramatically expanding identification of hereditary diseases in the prenatal period. This opens the do ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: Circumvent Pharmaceuticals Topic: NICHD
SummaryIn the Specific Aims outlined by the following proposal for an NIH SBIR Phase 1 project, we will use a multi-faceted approach to identify key substrates for targeted assay development to monitor therapy in for CLN1 Batten Disease (CLN1). CLN1 is an ultra-rare neurodegenerative disease that affects children with autosomal recessive mutations in the gene for palmitoyl-protein thioesterase 1 ( ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
Multi-modal cloud based system for detecting early signs of driver cognitive decline and/or high risk driving behaviorsSBC: PLCC2 LLC Topic: NIA
Project Summary/AbstractPhysical Sciences Inc. (PSI), in collaboration with Michigan State University (MSU) and the University of Michigan (U-M), proposes to develop a novel technology that will non-intrusively monitor driver cognitive decline and/or high-risk driving behavior that is especially suited for seniors (aged andgt;65). Contextual physiological biomarkers along with computer vision base ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: M2 Technologies LLC Topic: NIDCR
Project summary Cone beam computed tomography (CBCT) is a commonly used 3D x-ray imaging modality in dental and craniofacial imaging. While CBCT is primarily employed in evaluating bony anatomy in 3D, soft tissues are often poorly visualized in dental CBCT images. Moreover, tissue densities cannot be extracted accurately from CBCT images. The main culprit behind this problem is scattered radiation ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
Combined Cardiomyopathy, e.g., of Cancer Chemotherapeutics, and Proarrhythmia for Cardiotoxicity Clinical Trials-in-a-Dish (CTiD) with iPSC-Derived CardiomyocytesSBC: VALA SCIENCES, INC. Topic: NHLBI
Cardiotoxicity is a leading cause of drug discovery attrition across all of preclinical and clinical drug discovery. While the FDA and the Comprehensive in vitro Proarrhythmia Assay initiative (CiPA) are focused primarily on predicting proarrhythmic effects, drug attrition due to cardiomyopathy, or primary cardiac cytotoxicity, may be even more prevalent, is typically currently only carried out vi ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
SBC: ELECTRONIC BIOSCIENCES, INC. Topic: 172
Project Summary During this project, Electronic BioSicences (EBS) and Professor Meni Wanunu (at Northeastern University) will develop a true single-molecule, direct, long-lived, RNA sequencer. The developed RNA sequencer will be capable of sequencing RNA with high-accuracy (andgt;99%), as well as iteratively sequencing various samples and quantitatively profiling the RNA content of a given sample, ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health
A novel, hand-held, exhaled breath condensate sampler for the clinical research market; applications for asthma, pulmonary injury and inflammation.SBC: SENSIT VENTURES, INC. Topic: NIEHS
ABSTRACTExhaled breath is one of the most non-invasive human effluents that can be captured and analyzed, and yet it has minimal presence as a common clinical endpoint measurement in any branch of modern medicine. There has been a persistent technology gap for both breath sampling and breath analysis, despite the many vulnerable patient populations and age groups that could be aided by its use. Ex ...STTR Phase I 2021 Department of Health and Human ServicesNational Institutes of Health