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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Troponin Biosensor for Early Detection and Real-time Monitoring of Myocardial Infarction
SBC: EZ Lab Limited Liability Company Topic: NHLBIProject Summary Cardiovascular disease (CVD) is the leading cause of death for people in most racial and ethnic groups in the United States. Acute Myocardial Infarction (AMI) (also called heart attack) is the top cause of death in CVD. Early detection of AMI translates to earlier intervention and improves survival rates. When cardiac myocytes are damaged, cardiac troponin (cTn), a component of the ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
The First Non-Surgical Anti-Stomal Prolapse Medical Device to Treat and Prevent Stomal Prolapse
SBC: PEDIATRIC MEDICAL DEVICE COMPANY, LLC Topic: 300ABSTRACT Intestinal stomas such as ileostomies and colostomies are openings of the intestinal tract surgically exteriorized onto the abdominal surface to divert enteric content away from distal cancer, obstruction, inflammation, and infection 5. In the US alone, about 1.5 million people have stomas14. Prolapse, or protrusion, of the bowel through the stoma is a common complication that can cause p ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Development of a Bio-tissue Oxygenation Nanophosphor Enabled Sensing (BONES) system for Quantifying Hypoxia in Bone Marrow
SBC: SIGRAY, INC. Topic: 400Project Summary/Abstract Low oxygen (hypoxic) environments are known to be important for maintaining the small number of adult stem cells in the human body, such as in bone marrow. These conditions are also believed to enable dormant cancer cells to survive and metastasize years or decades after the original tumor has been destroyed and the reason why bone marrow is one of the most common sites of ...
STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health -
Rapid egg bioreactor construction for Fabry disease therapeutics
SBC: ATGC Inc. Topic: 300AbstractFabry disease is a lysosomal storage disease (LSD) affecting 1 in 40,000 to 117,000 live births. The current treatment is enzyme replacement therapy (ERT) with recombinant human α-galactosidase A (GalA). A major healthcare burden from this treatment is the high drug cost at $350k per patient-year.To reduce the drug cost for Fabry disease, we propose to develop a rapid approach to construc ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
New Agents for the Treatment on Mycobacteria Avium Infections
SBC: Quercus Molecular Design, LLC Topic: NIAIDAbstract: Non-Tuberculosis Mycobacteria (NTM) are responsible for widespread, life threatening infections of the lungs, skin, lymphatic and hematological systems. The rapid, global spread of resistant organisms has significantly reduced the number of agents that can be used effectively to treat these infections. Of specific clinical relevance are the slow-growing Mycobacterium avium complex (MAC) ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Development and characterization of HIV-1 Tat degraders
SBC: Thimble Therapeutics Inc Topic: NIAIDAbstractDespite effective antiretroviral therapy (ART), latent proviruses can reinitiate viral production upon cell stimulation or treatment interruption. The viral Tat protein enhances transcript elongation from the HIV-1 promoter, controlling the switch between latency and active viral production. The block-and-lock functional cure aims at the transcriptional silencing of the viral reservoir, re ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
A web-based platform to support team-based genome diagnostics
SBC: FRAMESHIFT LABS INC Topic: 172Summary/Abstract Genomic sequencing is rapidly becoming a standard tool in diagnosing complex diagnostic cases, especially in critically ill newborns, and patients suffering from rare diseases. Current programs focused on addressing these cases utilise a team-based approach to identify, interpret and evaluate a patient’s genetic variants. These diverse teams include bioinformaticians, medical ge ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Biomarker-enhanced Artificial Intelligence-Based Pediatric Sepsis Screening Tool Towards Early Recognition and Personalized Therapeutics
SBC: COMPUTER TECHNOLOGY ASSOCIATES, INC. Topic: NIAIDPROJECT SUMMARY The overall objective of this proposed STTR effort is focused on the derivation and validation of a commercialized biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) that can be incorporated into emergency department (ED) workflows to enhance early recognition and the initiation of timely, aggressive personalized sepsis therapy. The early r ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Solving Sepsis: Early Identification and Prompt Management Using Machine Learning
SBC: Cohere-Med, Inc. Topic: 300Abstract This fast-track STTR application proposes to enhance, validate, and scale Sepsis Watch, a deep learning sepsis detection and management system built using data from the Emergency Department (ED) Duke University Hospital (DUH). The proposal will extend and enhance Sepsis Watch to EDs, general inpatient wards, and intensive care unit (ICU) settings across multiple health systems in the Unit ...
STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health -
Novel methods to improve nuclease mediated homologous recombination
SBC: ATGC Inc. Topic: 400Project Summary The 2020 Nobel Prize in Chemistry was awarded to Drs. Emmanuelle Charpentier and Jennifer Doudna for their development of a revolutionary gene-editing tool, CRISPR/Cas9. It allows precise edits to the genome and has swept through the life science field. It has countless applications. Scientists hope to use it to develop therapeutic strategies for treating human genetic diseases. Ho ...
STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health