Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Algorithmic improvements in large scale polarizable QM/MM simulations

    SBC: Q-CHEM, INC.            Topic: 400

    Project Summary The goal of the project is to develop new algorithms and computer codes based on the continuous fast multipole method that will dramatically decrease the computational complexity of large scale modeling of redox processes and other bioand photo chemical reactions accompanying metabolic pathways of drug moleculesRedox processes are at the heart of various biological functionsincludi ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Accessible And Robust Tools for Glycosaminoglycan Profiling

    SBC: ECHELON BIOSCIENCES, INC.            Topic: 300

    GlycosaminoglycansGAGsare polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrixMore recentlychanges in the contentsizeand composition of GAGs have been found to play biological roles in disease processes as wellFor examplechondroitin sulfateCSis the most abundant GAGhoweveronly th ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. FitMi Plus: Smart Functional Modules for Practicing Activities of Daily Living after Stroke

    SBC: FLINT REHABILITATION DEVICES, LLC            Topic: NICHD

    Overof theindividuals who survive a stroke each year have persistent movement impairmentsIntensive rehabilitation could reduce their impairmentsbut access to such therapy is limitedHome therapy could supplement time with a therapistbut the current standard of care is simply providing individuals printed sheets of exercisesan approach that is not motivating and often not effectiveTechnological solu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. The use of selective NaV1.7 inhibitors to treat inflammation post-surgery

    SBC: CHROMOCELL CORPORATION            Topic: NIAID

    ABSTRACTNonsteroidal anti inflammatory drugsNSAIDsare the most commonly prescribed drugs to treat posttraumatic inflammation and painalthough they carry significant risk of seriousdose dependent adverse eventsCorticosteroidswhich are an alternative class of anti inflammatory drugsare rarely prescribed for post traumatic inflammationdue to adverse effects on wound healing and their lack of specific ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. A functional assay for ex vivo determination of drug susceptibility for multiple myeloma patients

    SBC: Travera LLC            Topic: 102

    Multiple myeloma is the second most common hematological malignancy and remains incurablewithof patients surviving less thanyearsPatient relapse is inevitable despite an increase in therapeutic optionshighlighting the significant need for predictive biomarkers that can rapidly and accurately determine tumor drug susceptibility to direct utilization of optimal therapiesWe will apply Travera s mecha ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Plant-derived molecular condom as an on-demand nonhormonal female contraceptive

    SBC: YourChoice Therapeutics, Inc.            Topic: NICHD

    Consumer behavior throughout the world points to a high level of dissatisfaction with currently available contraceptive methodsAlmost a third of American women discontinue using hormonal methods of birth control within the first yearwhileof men discontinue using condoms within the same timelineConsumers are not satisfied with either the continual methodshormonalor the on demand optionsuch as condo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Next Generation Visual Performance Assessment System for Rodents

    SBC: AFASCI, INC.            Topic: NEI

    PROJECT SUMMARY TitleDevelopment of a Next Generation Visual Performance Assessment System for Rodents Visual behavior abnormalities not only link directly to the retinal pathology and visual pathway disordersbut also associate with many neurodegenerative brain conditionsparticularly with Alzheimer s diseaseParkinson s diseaseand traumatic brain injuryThe optomotor reflexOMRconsists of innaterefle ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Nicotine Vapor Inhalation Chambers for Rodent Self-Administration

    SBC: LA JOLLA ALCOHOL RESEARCH INC            Topic: NIDA

    Project Summary This Phase II SBIR project will developoptimizetestcommercializeand take to market an inhalation chamber that mimics the e cigarette technology being used by human usersand being popularized by ecigarette manufacturers and advertisersE cigarette use and abuse is a major public health concernbut little is known about the biology underlying e cigarette use and negative health impact ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. A Novel Two-in-One Approach to Administer Surfactant and Provide Airway Support to VLBW Infants

    SBC: BB MEDICAL SURGICAL, INC            Topic: NICHD

    PROJECT SUMMARYABSTRACT Every yearvery low birth weightVLBWandltginfants are born in the U SThe use of surfactant dramatically decreases morbidity and mortality due to respiratory distress syndromeRDSin VLBW infantsCurrent standards for surfactant administration require the infant to be intubatedso that surfactant can be delivered to the trachea and lungsIntubating a VLBW infant is challenging and ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Eliminating Interference from Autofluorescence in Flow Cytometry

    SBC: Kinetic River Corp.            Topic: 400

    SUMMARY Flow cytometry is a powerful cell analysis toolproviding information on cell countshapesizeDNA contentredox statemembrane permeabilityand surface receptorsamong other featuresIt can be used on both live and fixed cellsand can be used to non destructively sort cells based on these characteristicsFlow cytometry has utility in research and clinical fields as diverse and important as tumor bio ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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