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This Small Business Innovation Research (SBIR) Phase II project intends to meet the need for low cost dose-on-demand production of Carbon-11 isotope for biomarker and radiotracer applications in nuclear medicine. Biomarkers and radiotracers are commonly used for Positron Emission Tomography and Computed Tomography (PET/CT) metabolic imaging, in support of research, drug discovery, and detection of ...

As the Navys fleet of Unmanned Air Systems (UAS) continue to grow so do the desired capabilities of these systems. Of specific interest is the extension of range and endurance through the use of autonomous aerial refueling. This presents a unique challenge to the control law development of the UAS as autonomous refueling can be susceptible to many external variables including atmospheric gusts and ...

Corvid is pleased to offer an innovative load path management solution to ensure the survivability of electronic fuze components in multi-frequency shock environments. Covids solution is superior to conventional encapsulation, potting, and underfill methods by offering mass efficient mitigation of damaging SRS conditions, increased structural integrity, and being detachable. Risk and development t ...

DESCRIPTION provided by applicant Tuberculosis TB is due to infection with the pathogen Mycobacterium tuberculosis Mtb This disease represents a global health pandemic as based on WHO statistics it claims the lives of approximately million people per year while infecting nearly million New drugs are urgently needed with novel mechanisms of action that treat this disease while also ...

DESCRIPTION provided by applicant Only of the human genome is translated into proteins whereas roughly is transcribed into RNA Complex higher order structures in these RNAs fundamentally affect critical biological processes As examples RNA structures in the ribosome are the targets of many antibiotics structures in the genomes of RNA viruses like HIV and influenza are essential for ...

Project Summary Abstract The goal of this proposal is to develop a novel high throughput platform for understanding gene regulatory elements in order to identify new drug targets for common diseases The human genome encodes approximately genes Understanding how those genes are regulated and how this correlates to complex cell phenotypes has long been a major focus of our team Follow up p ...

Project Summary Abstract Synthetic arteriovenous grafts AVGs can provide life sustaining vascular access for dialysis patients but are subject to multiple modes of failure and complications related to chronic needle cannulation poor graft identification delayed access and bleeding These graft needle cannulation associated complications translate to millions of dollars in health care expense ...

PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

DESCRIPTION provided by applicant Despite their increased risk of developing serious diseases including coronary heart disease Type diabetes hypertension certain types of cancers and stroke the public health crisis of individuals who are overweight or obese continues unabated Safety issues have hampered development of drugs designed to control weight and the four drugs currently on the ...

DESCRIPTION provided by applicant Directed Chemotherapy Delivery for Leptomeningeal Metastases PI Lad Shivanand and McCabe Aaron Project Summary Leptomeningeal Metastases LM is a condition in which cells from a primary solid or hematological tumor metastasize invade the subarachnoid space and spread throughout the cerebrospinal fluid CSF resulting in seeding of the leptomeninges along ...