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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 81 - 90 of 5421 results
  1. A Rapid Breath Test for Invasive Aspergillosis

    SBC: Volatylix, Inc.            Topic: NIAID

    Project Summary AbstractInvasive aspergillosisIAis a leading cause of morbidity and death in immunocompromised patientswith overmillion individuals at risk for IA and at leastIA cases developing worldwide each yearDespite the development of potent triazole antifungal drugs for the treatment of IAIA associated mortality is stillTimely and accurate diagnosis of IAin conjunction with prompt initiatio ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Compact Hybrid Magnet with High Homogeneity for X-Band DNP/NMR and EPR Spectroscopy

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: 400

    Project SummaryAbstract We propose to develop aT compact and portable hybrid magnet with high homogeneityandltppmandT of sweep rangeThe magnet system will be used in Overhauser Dynamic Nuclear Polarization experiments in the X Band for studying water dynamics in molecules and other analytical chemistry applicationsIn Phase Iwe will designbuild and test a prototype magnet to meet the above stated r ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Designing low-cost, customizable high-density probes for acute and chronic neural recordings in rodents

    SBC: Neural Dynamics Technologies LLC            Topic: 101

    SFProject Summary Understanding how the brain generates certain behaviors requires an understanding of the function of individual neurons in dynamical neural circuitsCurrentlythere are few technologies available however that allow researchers to record both the activity within a brain regionand between brain regions in the brains of awakebehaving animalsRecent advances in microelectrode fabricatio ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Reducing the incidence of febrile neutropenia in cancer patients treated with chemotherapy with PointCheck: a portable non-invasive neutropenia analyzer

    SBC: LEUKO LABS, INC.            Topic: 396

    Every year in the UScancer patients are treated with chemotherapyAs a side effecttheir neutrophil countsnumber of white blood cells that aid in fighting infectionsbecome lowreferred to as neutropeniaand expose them to febrile neutropeniaFNwhich are episodesof serious infection that entail costly hospitalization and sometimes deathIfneutropenia is detected earlyFN can be avoided through timely deli ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Bacterial delivery of phosphatase antagonists to metastatic breast cancer

    SBC: ERNEST PHARMACEUTICALS LLC            Topic: NCI

    Summary At this timethere is no cure for metastatic breast cancerThe prognosis for these patients is poorWith current standard of care treatmentsthe median survival time is three yearsWe propose to develop a novel bacterial drug delivery therapy into an effective and low toxicity therapeutic for breast cancer metastasesthat targets protein phosphatasePPAberrant phosphorylation in cell signaling is ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Bioactive Surface Engineering for High Yield Manufacturing of Dendritic Cell-Based Cancer Therapeutics

    SBC: FLASKWORKS, LLC            Topic: 100

    PROJECT SUMMARY Dendritic cellsDCare antigen presenting cells that identify and capture foreign bodies and play an essential role in activating both the adaptive and humoral immune responseDCs are an attractive vehicle for therapeutic manipulationparticularly in cancerand are used in antigen pulsed autologous DC therapies and DC stimulated autologous T cell therapiesHoweverdirect isolation of pati ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Technology-Enabled Therapy for Elders with Mild Cognitive Impairment and Co-morbid Insomnia

    SBC: Environment And Health Group, Inc.            Topic: NIA

    Abstract Mild cognitive impairmentMCIis often viewed as a transitional stage between normal aging and early stage of Alzheimer s disease and related dementiaMCI affects up toof the population of older adultsand sleep disturbances have been identified as one of the core neuropsychiatric problems in MCISleep disturbances are associated with a range of negative outcomes for persons with MCIincluding ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Modular Automated Platform for Large-scale Drosophila Experiments and Handling

    SBC: FLYSORTER, LLC            Topic: 101

    PROJECT SUMMARYABSTRACT Animal model systems are a powerful tool researchers use to investigate almost all aspects of biologygeneticsdevelopmentneurosciencediseaseand moreAnd fruit fliesDrosophila melanogasterwith their small sizeeasy careand remarkable array of available genetic toolkitsoccupy a sweet spot on the model organism spectrumOverof human diseases with a genetic basis have an analogue i ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells

    SBC: Giner, Inc.            Topic: NIDDK

    PROJECT SUMMARY Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells The overall goal of the SBIR project is to develop an advancedminiaturized implantable electrochemical oxygen generator that supplies oxygen at well regulated dose and concentration to cells within an immunoisolation deviceso as to ensure their viability and function at high density and minimize o ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Improved Amputee Quality of Life Enabled by Tailored, Self-Regenerating Energy Storage Device For Powered Prosthetics

    SBC: Giner, Inc.            Topic: NICHD

    PROJECT SUMMARY Improved Amputee Quality of Life Enabled by TailoredSelf Regenerating Energy Storage Device forPowered Prosthetics Poweredmotorized prosthetics enable users to more naturally perform taskssuch as climbing stairs or rising from a seated positionHowever because the power requirements fluctuate during the gait cyclethe current battery system is not energy efficient and also since ener ...

    SBIR Phase I 2018 Department of Health and Human Services

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