Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

Displaying 81 - 90 of 5599 results
  1. A retrievable autologous bioengineered esophageal implant as a novel treatment for long-gap esophageal atresia

    SBC: Biostage, Inc.            Topic: NICHD

    Esophageal AtresiaEAis a congenital birth defect characterized by a discontinuity of the esophagusEach year several thousand children are born within the EA spectrumBabies born with EA have trouble feedingand require a procedure to correct the abnormalityThe best treatment for EA is surgery reconnecting the two ends of the esophagus to each otherIn some childrenhoweverthe gap between the two esoph ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. RADECT is developing a clinical guidance (CG) software for nurse education and practitioners to evaluate experiential case-filesfor the purpose of augmenting health disparity/equity clinical care.

    SBC: RADECT INC.            Topic: 102

    Project Summary Abstract Our NIH SBIR project is to validate a Clinical Guidance System to assist practitioners in underserved and health disparity environmentsWe will apply our Clinical Guidance System for nurse educationThe Clinical Guidance System is being trained across diverse medical disciplines across various healthcare dataThis will then guide practitioners in diagnosis and treatment knowl ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Single clone discovery using an image-based cell isolation platform

    SBC: ENRICH THERAPEUTICS INC.            Topic: NIAID

    Under microscopeit is easy to identify cells of specific morphological phenotypes or interacting with other cell typesBut it is not trivial to pick the very cell out without submicron precision mechanical instrumentmicro pipetting or laser micro dissectionTo facilitate image based single cell isolationwe seek to develop an LCD aided selection under microscopeLASUMtechnology that will allow us to p ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. A universal mechanobiology tool for drug discovery in lung diseases

    SBC: Mechanobiologix L.L.C.            Topic: NHLBI

    Abstract Despite significant effortsno cure exists for the major respiratory diseases such as asthmaemphysema and pulmonary fibrosis due to a lack of proper preclinical methodsDrug development is often carried out in cultured cellsWhile amenable to imaging and manipulationthis approach lacks the native tissue environment and neglects the effects of mechanical forces due to breathing which influenc ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Integrated point-of-care diagnostic and data reporting platform for emerging arboviruses

    SBC: E25Bio Inc.            Topic: NIAID

    Overbillion people live in areas that are affected by the transmission of arthropod borne virusesarbovirusessuch as the flaviviruses dengueDENVand ZikaZIKVand the alphavirus chikungunyaCHIKVThese arboviruses are pathogenic and cause millions of infections annuallyWhile the surveillance is critical to understanding infection ratescontrolling outbreaksand informing patient therapeutic effortsthere i ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Mobile Health App to Reduce Diabetes in Latina Women with Prior Gestational Diabetes

    SBC: Environment And Health Group, Inc.            Topic: NIMHD

    AbstractDespite Latinos being the largest ethnic minoritywith almostmillion latinos living in the USthey are one of the most medically underserved groupsLatina women have one of the highest rates of gestational diabetes mellitusGDMin the U SMoreoverGDM is a major risk factor for typediabetesT DMwith up toof women developing T DM withinyears of a GDM pregnancyGiven the growing obesity epidemicrates ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Building a commercially scalable bionic pancreas for automated diabetes management

    SBC: Beta Bionics, Inc.            Topic: 200

    Through ayear collaboration between Boston UniversityBUand the Massachusetts General HospitalMGHwe have built insulin only and bihormonalconfigurations of our bionic pancreasBPand extensively tested them in inpatientoutpatientand real world home use studies in people with typediabetesT DWe have also conducted preliminary clinical studies testing the insulin only configuration of our BP in people w ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Prescription Digital Therapeutic to Promote Adherence to Buprenorphine Pharmacotherapy for Patients with Opioid Use Disorder

    SBC: Pear Therapeutics, Inc.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid Use DisorderOUDis a key driver of the current opioid epidemic in the United StatesNearlyof individuals with OUD do not receive treatmentBuprenorphine Medication Assisted TreatmentMATis an effective form of care for OUDBuprenorphine ameliorates craving and withdrawaland reduces illicit opioid usemortalityand problems associated with drug useHoweveradoption of bupreno ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Targeted long-read sequencing sample preparation using Cas9 nucleases

    SBC: Sage Science, Inc.            Topic: 172

    Project Summary DNA sequencing is increasingly being used in clinical research in genetic disease and oncologyCurrently most clinical sequencing is carried out using short read targeted sequencing methods to detect mutations in protein coding regions of the genomeHowevershort read sequencing methods are not well suited to detection of alterations involving DNA segments greater thanbase pairs in le ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Smartphone-based rewards as a bridge to treatment for naloxone reversal patients

    SBC: DynamiCare Health, Inc            Topic: NIDA

    ABSTRACT Opioid overdose is a major public health crisisand a clear sign of problem drug useMany people who experience an overdose receive a naloxone reversal and are treated in a hospital emergency departmentHoweverfew overdose survivors enroll in treatmenteven if they receive care and referral to treatment while in an emergency departmentMedication assisted treatmentsMATsuch as methadone or bupr ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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