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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Microfluidic Cell Culture Array for Predictive Toxicity Screening

    SBC: CELLASIC CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The main objective of the Phase II proposal is to further develop the microfluidic cell culture array for high quality cell-based life science applications in the pharmaceutical and biotechnology industry. This will focus on predictive hepatotoxicity screening, which has been included as one of the Critical Path Initiatives by the FDA to provide additional pre- ...

    SBIR Phase II 2007 Department of Health and Human Services
  2. High Throughput Screening of Peptide Pharmaceuticals

    SBC: Cellecta, Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into a rational drug discovery process. Unfortunately, this is at present challenging, primarily due to the limited choice of suitable toolsets to rapidly delinea ...

    SBIR Phase I 2007 Department of Health and Human Services
  3. Functionally Validated Lentiviral siRNA Libraries

    SBC: Cellecta, Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into an operational cell-based model. Unfortunately, this is at present challenging, primarily due to the absence of suitable toolsets to rapidly delineate gene fu ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. Algorithm and genome-wide database of functional siRNAs

    SBC: Cellecta, Incorporated            Topic: N/A

    DESCRIPTION (provided by applicant): Despite the recent completion of the human genome project, an ostensibly more difficult post-genomic challenge will be the functional annotation of all human genes and integration of this information into an operational cell-based model. Unfortunately, this is at present challenging, primarily due to the absence of reliable experimental and bioinformatic tools ...

    SBIR Phase II 2007 Department of Health and Human Services
  5. Attenuation of Radiation-Induced GI Injury by Cultured Myeloid Progenitors

    SBC: Cellerant Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Our long term goal is to develop a universal cell-based therapy containing human myeloid progenitor cells to attenuate radiation-induced gastrointestinal or hematopoietic injury. Radiation (XRT) remains an important therapeutic modality in the treatment of malignancies. Injury to the gastrointestinal tract (GI) and hematopoietic system are serious sequelae of r ...

    STTR Phase I 2007 Department of Health and Human Services
  6. A RAPID, SENSITIVE, AND LOW-COST GENE EXPRESSION PROFILING TECHNOLOGY FOR CANCER

    SBC: Chembionics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Current methods of cancer classification and diagnosis utilize mostly histological and morphological properties of the tumor, leading to generic and often unsuitable treatments for patients. Recent genomic advancements in oncology have established the ability to perform gene expression profiling of cancers, which can guide health workers towards a more patient ...

    SBIR Phase I 2007 Department of Health and Human Services
  7. Discovery of Small Molecule hACC2 Inhibitors for Treatment of Obesity

    SBC: Chemdiv, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Acetyl-CoA carboxylase (ACC) is a key enzyme of fatty acid metabolism required for the addition of CO2 to acetyl-CoA to make malonyl-CoA. In mammals, malonyl-CoA serves as a precursor for the synthesis of fatty acids but it also regulates fatty acid oxidation in mitochondria. There are two ACC isozymes in humans, with very similar amino acid sequences, differin ...

    SBIR Phase I 2007 Department of Health and Human Services
  8. Topical Adjuvants to Enhance the Efficacy of Influenza Vaccines

    SBC: LANCELL, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): An adequate medical response to the threat of pandemic influenza includes surveillance and isolation, a sufficient supply of antiviral drugs, and rapid development of a protective vaccine. Under optimal circumstances, production of enough vaccine to protect the US population would take 6 months. A lag time of 6 months between identification of a pandemic strain ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Novel Puerarin Analogs with Anti-Diabetic Activity

    SBC: COMBINIX, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): In diabetics, hyperglycemia is most pronounced following a meal due to the absorption of glucose from the GI tract. Inhibiting glucose uptake in the intestines and/or promoting glucose disposal in the tissues may be beneficial for diabetic patients to control the blood glucose level in the postprandial state. We have recently demonstrated that puerarin, the maj ...

    SBIR Phase I 2007 Department of Health and Human Services
  10. A PERSON PORTABLE FAST RESPONDING EXHALED BREATH ANALYZER

    SBC: CONTEMPORARY DEVICES COMPANY            Topic: N/A

    DESCRIPTION (provided by applicant) It is proposed to develop (during phase I and II) a person portable, highly sensitive and selective, broad band, real time data acquisition, GPS enabled and remotely accessible by wireless or by internet a "Personal Exposure Monitor" for the detection of trace amounts of harmful chemical species present in the exhaled breath of a human being. This instrum ...

    SBIR Phase I 2007 Department of Health and Human Services

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