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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. High-Energy Imaging in Support of Radionuclide Therapy

    SBC: ALPHAMED, INC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to design and build cameras that can efficiently detect and image isotopes that have gamma rays with energies that are typically beyond those effectively accessible with conventional cameras. There are no nuclear medicine clinical cameras, today, that combine high efficiency with the ability to image high-energy gamma rays. ...

    STTR Phase I 2006 Department of Health and Human Services
  2. Novel Methods for Molecular Analysis of Colorectal Polyps

    SBC: AMBERGEN, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Considerable evidence has shown that cancer fatalities can be dramatically reduced through early detection and removal of premalignant adenomatous polyps by colonoscopy. However, as the demand for colonoscopy keeps increasing, capacity constraints pose a formidable ...

    SBIR Phase I 2006 Department of Health and Human Services
  3. A Novel-Invasive CRC Test Based on Mass Spec of In Vitro Expressed Proteins

    SBC: AMBERGEN, INC            Topic: N/A

    DESCRIPTION (provided by applicant): There exists an urgent need to develop an effective, non-invasive method for large-scale colorectal cancer (CRC) screening, the second leading cause of cancer deaths in the U.S. Such non-invasive testing, if instituted for a large segment of the population, could result in a dramatic reduction in the approximately 56,000 annual deaths caused by CRC. However, cu ...

    SBIR Phase I 2006 Department of Health and Human Services
  4. BIODEGRADABLE POLYMER ENCAPSULATED NANOPARTICLES FOR ORA

    SBC: APHIOS CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 2006 Department of Health and Human Services
  5. Computer Based Training for Contingency Management: Phase I

    SBC: CBT4CBT, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Bridging the gap between science and practice remains a significant concern in the effective delivery of treatments for drug abuse. Contingency management (CM) treatments, an empirically supported therapy, is well positioned to bridge this gap. Recent studies demonstrate the efficacy of CM in improving outcomes of substance abusers in community-based clinical s ...

    SBIR Phase I 2006 Department of Health and Human Services
  6. Advanced Robotic Device for the Safe Rehabilitation for Stroke and Brain Injury

    SBC: Barrett Technology Inc            Topic: N/A

    DESCRIPTION (provided by applicant): It is the long-term objective of this proposal to develop a cost-effective robotic rehabilitation machine that safely improves and accelerates a person's recovery outcome after a stroke or traumatic brain injury by enhancing neural rewiring. By the end of Phase-ll, a human-scale machine will be built and validated that is both safe and enables full and precise ...

    SBIR Phase I 2006 Department of Health and Human Services
  7. Development of a one-step isothermal DNA amplification system for diagnostics

    SBC: BIOHELIX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Molecular diagnostic tests that rely on the amplification of specific sequences to identify genes of interest frequently use the polymerase chain reaction (PCR). To perform PCR, sensitive and, often, expensive instrumentation is required for thermocycling, which facilitates heat denaturation, primer annealing and primer extension by a thermostable DNA polymeras ...

    SBIR Phase I 2006 Department of Health and Human Services
  8. A Mucosal Vaccine for HSV-2

    SBC: Biomedical Research Models, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 1 out of every 5 Americans is infected with herpes simplex virus type 2 (HSV-2). Localized genital infection by HSV-2 results in painful recurring genital lesions while disseminated infection can involve multiple visceral organs and lethal encephalitis. We have developed a new heterologous immunization protocol composed of a DNA vaccine follow ...

    SBIR Phase I 2006 Department of Health and Human Services
  9. Rapid Diagnostic Testing of Urinary Tract Infections

    SBC: BIOSENSE TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of a new rapid diagnostic method for testing the antibiotic susceptibility of urinary tract infections is proposed. The technical approach is based on a novel implementation of impedance sensing to monitor cellular growth with exceptional sensitivity and stability avoiding the need for grown cultures to obtain results. Susceptibility results can ...

    SBIR Phase I 2006 Department of Health and Human Services
  10. Production and characterization of ubiquitin proteins

    SBC: BOSTON BIOCHEM, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Well-defined and novel ubiquitin derivatives would be invaluable tools for basic research and drug discovery efforts, but these are commercially unavailable. We propose in this Phase I SBIR grant to develop a comprehensive panel of ubiquitin variants, making all combinations of lysine mutations and N-terminal modifications, as well as a collection of N-terminal ...

    SBIR Phase I 2006 Department of Health and Human Services

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