List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Novel serotonergic, pro-cognitive antipsychotic therapies

    SBC: Galenea Corporation            Topic: NIMH

    DESCRIPTION (provided by applicant): This application, Novel serotonergic, pro-cognitive antipsychotic therapies , is in response to PA-08-142: Pharmacologic Agents and Drugs for Mental Disorders (SBIR [R43/R44]). Schizophrenia is a devastating brain disorder that affects approximately 0.7% of the global population. The symptoms of schizophrenia can be grouped into three major categories: posit ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. In vitro tools for preclinical analysis of cognitive therapies for schizophrenia

    SBC: Galenea Corporation            Topic: NIMH

    DESCRIPTION (provided by applicant): Schizophrenia is a debilitating disease that afflicts 1% of the US population. Symptoms of schizophrenia are classified into three categories: positive (delusions and hallucinations), negative (flattened affect, socialisolation) and cognitive (impaired attention, executive function, working memory). Existing antipsychotics, while effective at treating the posit ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Benzodiazepine Analogs as Novel Treatments for Catatonia

    SBC: Organix Incorporated            Topic: NIMH

    DESCRIPTION (provided by applicant): Catatonia is a widespread and serious syndrome characterized by mutism, stupor, refusal to eat or drink, posturing, and hypokinesis, and affects a broad range of psychiatric and other patients in the US and worldwide. Untreated or poorly managed catatonic patients suffer from a wide range of ailments including bed sores, deep venous thrombi, pulmonary emboli, u ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Forced Exercise: A New Therapy for the Treatment of Parkinson's Disease

    SBC: EXERCYCLE COMPANY            Topic: NINDS

    DESCRIPTION (provided by applicant): A small pilot study by Alberts and team (Cleveland Clinic) suggests that sustained forced exercise (FE) may be as or more effective than medication or surgical implantation of microelectrodes for deep brain stimulationin improving motor function in individuals with Parkinson's disease (PD). In FE, an individual actively exercises at a rate in excess of th ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Web-based Self-Management of Chronic Pain in Parkinsons Disease

    SBC: Inflexxion, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Parkinson's Disease (PD) is a progressive, incurable neurodegenerative disease that affects more than 1.5 million people in the United States; or one out of every 100 people over the age of 60. Recent focus on the non-motor elements of PD has deepened the understanding of disability in this condition; and highlights the fact that chronic pain is an importa ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. A device for rapid, painless, bedside muscle evaluation of children

    SBC: Myolex Inc            Topic: NINDS

    DESCRIPTION (provided by applicant): Our goal is to provide neurologists and other clinicians a method for the rapid, painless, non-invasive evaluation of children with neuromuscular disease. Pediatric neuromuscular disorders include muscular dystrophies, spinal muscular atrophy, and inflammatory myositis, and affect well over 100,000 children in the United States alone. Present-day clinical m ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Cell-based Model for Electrical Stimulation Safety Studies

    SBC: EIC LABORATORIES, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): Cell-based Model for Electrical Stimulation Safety Studies The development of an in vitro, cell-based model to evaluate the effects of electrical stimulation on central nervous system (CNS) cells is proposed. Themodel would be used to establish likely injurious and non-injurious levels of stimulation in prostheses and therapies that employ electrodes chro ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Novel RNAi therapy for ALS and other Neurodegenerative Disorders

    SBC: RXI PHARMACEUTICALS CORPORATION            Topic: NINDS

    DESCRIPTION (provided by applicant): Project Summary / Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the central nervous system. Degeneration of the motor neurons results in paralysis and eventual death, usually due to respiratory failure. In a subset of cases, ALS is caused by dominantly transmitted mutations in the gene en ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Tr1-Specific Tolerance: a Novel Treatment of Multiple Sclerosis

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): We are developing a novel immunomodulatory therapy, hR-411, to treat relapsing-remitting multiple sclerosis (RRMS). hR-411 restores regulatory T-cell balance by redirecting pathogenic Th1/Th17 cells into tolerance-inducing Tr1 cells. hR-411 is formed from the fusion of human Ig-Fc and CXCL11, a CXCR3-binding ligand that has been recently identified as a cou ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. High Throughput Manufacturing for Three-Dimensional Microfluidic Devices

    SBC: FEMTOFAB, INC.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Manufacturing based on photolithography has been responsible for ushering in the microelectronics era with enormous societal and economical impact. Extending microfabrication technology to 3D has the potential to revolutionize many diverse fields including biomedicine, energy conversation and storage, and photonic device manufacturing. While many 3D microfabric ...

    SBIR Phase I 2011 Department of Health and Human Services

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government