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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel RNAi therapy for ALS and other Neurodegenerative Disorders

    SBC: RXI PHARMACEUTICALS CORPORATION            Topic: NINDS

    DESCRIPTION (provided by applicant): Project Summary / Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons in the central nervous system. Degeneration of the motor neurons results in paralysis and eventual death, usually due to respiratory failure. In a subset of cases, ALS is caused by dominantly transmitted mutations in the gene en ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Tr1-Specific Tolerance: a Novel Treatment of Multiple Sclerosis

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NINDS

    DESCRIPTION (provided by applicant): We are developing a novel immunomodulatory therapy, hR-411, to treat relapsing-remitting multiple sclerosis (RRMS). hR-411 restores regulatory T-cell balance by redirecting pathogenic Th1/Th17 cells into tolerance-inducing Tr1 cells. hR-411 is formed from the fusion of human Ig-Fc and CXCL11, a CXCR3-binding ligand that has been recently identified as a cou ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds Project Summary: In the chemical manufacturing of pharmaceutical compounds, organic syntheses are often carried out in organic solvents and involve intermediates and final products with high added value. These pharmaceutical active compounds having molecular weights in the range of 300-200 ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Low Light Level Camera For Raman Spectroscopy

    SBC: B & W Tek Inc.            Topic: NCRR

    DESCRIPTION (provided by applicant): Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of diseases and in situ evaluation of living tissues. However, the application of Raman spectroscopy for tissue evaluation has been limited by the strong tissue fluorescence that often overwhelms the extremely weak Raman signal. The goal of this proposal is to develop an infrare ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Enhanced Fluoropolymer Membrane Reactors for Production of Pharmaceutical Interme

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The commercial syntheses of many pharmaceutical active ingredients and intermediates require acid catalysts and the removal of water to drive reactions to completion. Typical reactions include esterifications of carboxylic acids with alcohols, Friedel-Crafts acylations and alkylations, Schiff base, acetal and ketal formation and nitrations of aromatic compounds ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Improving health benefits of wheat by increasing resistant starch

    SBC: Arcadia Biosciences, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): The conditions of diabetes and obesity are a growing public health concern affecting more of the population every year. A large segment of the population is pre-diabetic potentially progressing towards diabetes. Food choices impact all of these health problems. The overall goal of this proposal is to increase resistant starch levels in wheat, a principle part o ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. An Intelligent Capsule Endoscopy Video Analysis Software Platform

    SBC: Xyken, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Gastrointestinal (GI) malignancies are the most common cause of cancer in the world. Of the 10.8 million people in the world each year who develop cancer, approximately 3.3 million have GI malignancies. Until recently,the only sections of the GI tract that could be imaged were the esophagus, stomach and colon through traditional endoscopy. Initial segments of t ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. High Throughput Manufacturing for Three-Dimensional Microfluidic Devices

    SBC: FEMTOFAB, INC.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Manufacturing based on photolithography has been responsible for ushering in the microelectronics era with enormous societal and economical impact. Extending microfabrication technology to 3D has the potential to revolutionize many diverse fields including biomedicine, energy conversation and storage, and photonic device manufacturing. While many 3D microfabric ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. High Performance, Low Cost PET Scintillators

    SBC: Radiation Monitoring Devices, Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a functional imaging technique with the potential to quantify the rates of biological processes in vivo. The availability of short-lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine allows virtually any compound of biological interest to be labeled in trace amounts and introduced into the b ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Compact Hydrogen Peroxide Sensor for Sterilization Cycle Monitoring

    SBC: Physical Sciences Inc.            Topic: NIBIB

    DESCRIPTION (provided by applicant): Improper or incomplete sterilization of manufacturing facilities is a major cause of pharmaceutical product recalls. The economic and societal impact of these recalls is significant and difficult to quantify. Many pharmaceutical companies use vapor phase hydrogen peroxide (VPHP) to decontaminate and sterilize production facilities, including barrier isolators. ...

    SBIR Phase I 2011 Department of Health and Human Services

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