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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Hiltonol provides potent neuroprotection from ischemic brain injury in stroke.

    SBC: Oncovir            Topic: NINDS

    DESCRIPTION (provided by applicant): Brain ischemia is a leading cause of morbidity and mortality in the United States. We seek to develop therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain, anarea of significant unmet medical need. We have shown that ligand activation of the Toll-like receptor (TLR) family of pattern recognition recep ...

    SBIR Phase I 2013 Department of Health and Human Services
  2. Development of a Porcine Model of Juvenile Neuronal Ceroid Lipofuscinosis

    SBC: EXEMPLAR GENETICS, LLC            Topic: NINDS

    DESCRIPTION (provided by applicant): Juvenile neuronal ceroid lipofuscinosis (JNCL), also known as Batten disease, is an autosomal recessive disorder caused by mutations in the CLN3 gene with a worldwide incidence of 1 in 12,500 live births. It is part ofa group of lysosomal storage disorders - the neuronal ceroid lipofuscinoses (NCLs) - that together constitute the most common neurodegenerative d ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. Angiocidin, a Novel Differentiation Agent for the Treatment of Leukemia

    SBC: ALTEC Inc            Topic: NINDS

    DESCRIPTION (provided by applicant): The overall objective of this SBIR project is to develop a pre-commercial prototype system capable of continuously monitoring involuntary movement disorders from a wide spectrum of neurological conditions. The impact ofthis innovation will enhance the availability of advanced brain and behavior research tools [PA- 11-134] by providing a continuous means of trac ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. Media-based culturally-relevant parent education for divorced Latino families

    SBC: HELIXBIND INC.            Topic: OD

    DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project will establish feasibility of a novel method for detecting and diagnosing polymicrobial infections in biomedical laboratory animals. Polymicrobial infections in laboratory animals are of significant concern to the research community as they have a demonstrated detrimental effect on experimental outcome. It ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. Adapting wireless glucometer to boost opioid dependence medication compliance

    SBC: Ginkgo BioWorks            Topic: NCATS

    DESCRIPTION: Plant-derived secondary metabolites have proven to be a rich source of pharmaceuticals. From 1981 to 2010, over 65% of the 1355 new chemical entities introduced worldwide were natural products or natural product derivatives. The benzylisoquinoline alkaloids (BIAs) represent a diverse class of secondary metabolites (2500 known structures) with a broad range of pharmacological activiti ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Plasticity-based Adaptive Cognitive Remediation program (PACR) for the treatment

    SBC: CADUCEUS WIRELESS INC            Topic: NIA

    DESCRIPTION (provided by applicant): The overall objective of this Fast Track SBIR application is to create and deploy an innovative system that will help more elders to continue living at home while being safely cared for by Personal Care Service (PCS) agencies. Based on the research team's prior experience developing fall sensors and other technologies to allow elders to age in place , we ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Developing and Scaling an interactive text messaging tool to help pregnantsmoker

    SBC: Voxiva, Inc            Topic: NIDA

    DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking cessation among pregnant women. This project aims to develop the first-ever text message based smokin ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. Novel 5-methylcytosine Oxidases

    SBC: NEW ENGLAND BIOLABS, INC.            Topic: NIGMS

    DESCRIPTION: With the recent discovery of 5-hydroxymethylcytosine in mammalian DNA and the TET enzyme family responsible for its generation, it is clear that the mammalian DNA epigenome is much more complex than had been thought. A lot of questions remainto be answered about the in vivo roles and the in vitro properties of the TET enzymes. In this fast-track application, we propose studying the TE ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. A Functionalized Nanoparticle-Based handheld Device for Rapid and Sensitive Detec

    SBC: BRIDGE 12 TECHNOLOGIES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The proposed research focuses on the development of a DNP-NMR system for Dynamic Nuclear Polarization (DNP) enhanced solid-state NMR spectroscopy at 400 MHz. High-resolution structures are essential to the understandingof the complex functions of bio-macromolecules and NMR spectroscopy is a major source for such information. However, the method suffers from an ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. CM-65, a Targeted Contrast Agent for Cardiac Magnetic Resonance Perfusion Imaging

    SBC: Collagen Medical, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Assessment of myocardial perfusion is a gatekeeper diagnostic exam that has high sensitivity for identifying individuals with ischemic heart disease. Millions of perfusion studies are performed annually in the US usinga stress/rest paradigm with a radioactive tracer followed by nuclear imaging. While this is an effective exam, it involves delivering a dose of i ...

    SBIR Phase I 2013 Department of Health and Human Services

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