Award Data

The novel SARS coronavirus (SARS-CoV-2) global pandemic has taken a strong foothold and it is estimated that it will infect hundreds of millions of people, with millions dying. These estimates underscore the severity of the COVID-19 disease, caused by SARS-CoV-2, yet there are currently no effective treatments that can be administered to infected individuals. Our approach centered around a proprie ...

Acute respiratory distress syndromeARDSafflicts aboutAmericans each yearThe pathology consists of rapid onset of respiratory symptoms including radiographic bilateral opacities and pulmonary edemaThe primary risk factors for the development of ARDS are pneumoniaaspirationmajor traumasepsisand inhalation injuryDespite the adoption of lung protective ventilationthe mortality rate remains aboutCommon ...

Motoneurons are the final neural circuits that link the brain with skeletal muscles to enable the body to move. Impairments in the ability to regulate movement currently affect over 50 million Americans suffering from various neurological or musculoskeletal conditions. Yet the deficits in motoneuron control that underlie many of these conditions are difficult to discern because current research to ...

In the Phase I Base period, Anti-Jam (A/J) enhancements exceeding 40 dB were demonstrated with operational RT-1944/U radios. During the Phase I Option period, the system will be tested against a wider range of data rates and interference conditions, and an advanced Low Rate Initial Production (LRIP) prototype currently being completed for UHF SATCOM applications will be modified to provide an init ...

ABSTRACT Osteoporosis directly affectsmillion Americans and anothermillion are osteopenic and at risk for developing osteoporosisPostmenopausal osteoporosis is most commonbut osteoporosis does also frequently affect older menAt MAX BioPharmawe are developing new and improved therapies for osteoporosis that aim to rebalance both bone formation and resorption based on a dual therapy approachBisphosp ...

ABSTRACT:The objective of this effort is to perform tasks associated with development and maturation of Universal Serial Bus (USB) port security technology for securing Air Force systems from attack and data loss over USB.The proposed demonstration promises significant improvements in USB port security.Improved hardware and software will be needed to address the current Air Force IT security gap r ...

1. PROJECT SUMMARY/ABSTRACT Omniox is developing a unique oxygen delivery protein, OMX, as a treatment to preserve myocardial and peripheral organ function and significantly reduce morbidity after neonatal cardiopulmonary bypass (CPB) during surgical correction of congenital heart disease (CHD). Of the ~40,000 children born annually with CHD, ~10,000 require urgent surgery to repair heart defects. ...

The CDC reports that food allergy incidence in the U Sis risingwithof children now afflicted andhaving a history of severe and potentially life threatening reactionsIn order to reduce this high incidencenew guidelines recently issued by the NIAID and also by leading allergists recommend that children betweenmonths of age be introduced to highly allergenic foods such as peanutsmilk and eggsIn addit ...

Pterygium is an ocular surface disease with abnormal fibrovascular growth on the cornea that affects aboutmillion individuals in the USLater stage disease impairs vision and the current standard of care is surgical removal of lesion tissueHoweverlesions recur in aboutof patients after surgeryBecause there is no approved drug to treat pterygiumwe propose to address this unmet medical need with a to ...

DESCRIPTION provided by applicant The congenital long QT syndrome LQTS is thought to occur in in infants and cause of deaths from SIDS sudden infant death syndrome Electrocardiograms ECGs can detect LQTS before fatal cardiac events happen In our Phase I STTR project we successfully developed and tested an ECG device designed for LQTS screening in newborns This device n ...