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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 81 - 90 of 3407 results
  1. Sustained release of next-generation aptamers to treat wet AMD

    SBC: Aptitude Medical Systems, Inc.            Topic: NEI

    Abstract SignificanceWet AMD affectsM Americans and is the leading cause of blindness in those agedor olderVision improvement from anti VEGF treatment is neither permanent nor completeand patients must receive intravitreal injections everymonthscreating a major treatment burden for patientsphysicians and payersEmerging combination therapies could address the efficacy problembut they do not solve t ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Anti-inflammatory bioconjugates for sustained inhibition of post-traumatic osteoarthritis following joint injury

    SBC: Valitor, Inc.            Topic: NIAMS

    Project Summary Inan estimatedmillion Americans experienced symptoms of osteoarthritisOAthat could be associated with a known joint injuryDue to a lack of disease modifying therapiesjoint replacement surgery is often the only treatment option to eliminate the associated discomfort and restore mobility for patients with post traumatic osteoarthritisPTOAAnti inflammatory therapy has been proposed to ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Development of a thermostable, electron beam inactivated Sabin-based polio vaccine for mucosal delivery

    SBC: UNIVERSAL STABILIZATION TECHNOLOGIES, INC            Topic: NCIRD

    Project Summary AbstractInactivated Polio VaccineIPVand Oral Polio VaccineOPVmanufactured today are both unstable at high ambient temperaturesi eCand require maintenance of a cold chain to prevent potency loss during transportation and storageOPV is most sensitive to heatand IPV is sensitive to both freezing and elevated temperaturesOPV live vaccinescreated from attenuated Sabin strainsare shed fr ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Design and clinical evaluation of a smartphone-based low vision enhancement system

    SBC: Visionize LLC            Topic: N

    Project Summary Visionize has developed a sophisticated wearable state of the art low vision aid by reprogramming a readily available low cost off the shelf Virtual Reality systemThe device operates in three main modesThe patient views the real world with adjustable magnification power and area within the overall sceneThe patient also has access to the full complement of digital media ranging from ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Saliva biomarkers for predicting outcome in pediatric and adult patients with severe and moderate TBI

    SBC: GAIA MEDICAL INSTITUTE, LLC, THE            Topic: NCIPC

    PROJECT SUMMARY Saliva biomarkers for predicting outcome in pediatric and adult patients with severe and moderate TBI Traumatic brain injuryTBIis a leading cause of mortality and morbidity around the worldwith increasing incidenceIn the USTBI is a contributing factor toof all injury related deathsPatient with more severe TBI injuriessTBIare more likely to require hospitalization and suffer long te ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Building a commercially scalable bionic pancreas for automated diabetes management

    SBC: Beta Bionics, Inc.            Topic: 200

    Through ayear collaboration between Boston UniversityBUand the Massachusetts General HospitalMGHwe have built insulin only and bihormonal con gurations of our bionic pancreasBPand extensively tested them in inpatientoutpatientand real world home use studies in people with typediabetesT DWe have also conducted preliminary clinical studies testing the insulin only con guration of our BP in people wi ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Novel Proximity Assay Platform for the Quantitative Detection of Hepatitis B Virus Surface Antigen

    SBC: Ocean Nano Tech LLC            Topic: NCHHSTP

    SummaryThis proposal aims to develop a novel proximity technology to quantify the hepatitis B virusHBVsurface antigenHBsAgin blood for point of care testingHBsAg is an important serological marker that is highly predictive of HBV infection statusand response to anti viral treatmentChronic infection with HBV is a serious global health problem and among the leading causes of preventable deathThere a ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Phase 2a Multicenter, Randomized, Vehicle-Controlled, Dose Escalating Study to Evaluate the Safety, Efficacy and Pharmacokinetics of CBT-001 Ophthalmic Solution in Pterygium Patients

    SBC: CLOUDBREAK THERAPEUTICS LLC            Topic: N

    Project Narrative Pterygium is an eye disease without any approved drug treatmentsurgery is the only option when vision is impacted and rapidly growing lesions recur in aboutof patients after surgeryThe proposed fast track project is to perform a Phasea clinical trial to evaluate the safety and efficacy of a novel pharmacological therapy that could change the standard of care of pterygium treatmen ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Reverse Engineering and Manufacturing of Alternative Display Equipment

    SBC: Intellisense Systems, Inc.            Topic: DLA182004

    To address the Defense Logistics Agency (DLA)s need for KWD-ML-4-115AL alternative supply sources, Intellisense Systems, Inc. (ISI) proposes to develop a new Reverse Engineering and Manufacturing of Alternative Display Equipment (RE-MADE) process specifically to reverse engineer (RE) the KWD-ML-4-115AL display to improve product availability and increase competition. The proposed RE process is bas ...

    SBIR Phase I 2018 Department of DefenseDefense Logistics Agency
  10. Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells

    SBC: Giner, Inc.            Topic: NIDDK

    PROJECT SUMMARY Pressure Management Technologies for Oxygenation of Implanted Insulin Secreting Cells The overall goal of the SBIR project is to develop an advancedminiaturized implantable electrochemical oxygen generator that supplies oxygen at well regulated dose and concentration to cells within an immunoisolation deviceso as to ensure their viability and function at high density and minimize o ...

    SBIR Phase II 2018 Department of Health and Human Services

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