Award Data

Project Summary Worldwidetens of millions are afflicted with chronic migraineCMa highly debilitating neurological disorderWhile abortive and preventative therapies existthere are still nearlymillion peopleM in the US alonewho do not respond adequately to these therapies and suffer from Intractable Chronic MigraineICMThose patients are highly disabled by their disease and are faced with a significa ...

Project Summary Abstract This Phase II project aims to develop an automated system for extracting mesenchymal stem cellsMSCsalso known as multipotent stromal cellsfrom adipose tissues for treating many serious diseasesincluding myocardial infarctiongraft versus host diseaseand a variety of autoimmune diseasesOverclinical trials to date have established the feasibilitysafetyand in some cases effica ...

AbstractCannabinoids are a class of natural products shown to treat a wide range of diseasesincluding epilepsyone of the most common neurological disordersEpilepsy affects people of all ageswith overmillion epileptics worldwide and overnew cases of epilepsy each year in the United States aloneEven with numerous anti epileptic drugsAEDavailableof patients have uncontrollable seizures that do not re ...

Large vessel acute ischemic strokeAISis the leading cause of disability and fourth leading cause of death with approximatelyper year in the United States aloneAlthough treatments including interventionalstentrieverand pharmaceuticaltPAexist for large vessel occlusionLVOthere is not a rapid prehospital tool for diagnoses which guides the use of the correct therapyBecause the time to treatment for s ...

Commercialization of HaploSeq as a ServiceHaaSfor generating chromosome span phased genome and exome sequence information Arima Genomics SPECIFIC AIMSProject Summary Abstract Overof Next Generation SequencingNGSis sequenced via Illumina short read sequencersThis is because of its cost effectiveness and faster turn around timesHowevershort read sequencing technologies lose critical contiguity infor ...

PanHIV Incidence Assay DevelopmentAbstractHIVcontinues to cause the largest number of yearly deaths from a single infectious agent in the world todayDespiteconsiderableadvancesintreatmentofHIVinfectionandAIDSwhichitcausesthereisanurgentneed for better methods of prevention and treatment of HIVinfection and AIDSAs part of this effortthe WorldHealth OrganizationWHOand the Joint United Nations Progra ...

PROJECT SUMMARY The goal of the current Phase I project is to developto clinical trial readinessand evaluate the feasibility and initial efficacy of a mobile applicationHeartMappdesigned to monitor and treat physical and cognitive symptoms related to heart failureHFin older adultsHeart failureHFis a leading cause of death in the US with costs estimated at $billion per annumfueled by the high rates ...

DiscoveryofYellowFever VirusSpecificEpitopesforDevelopmentofanAccurateSerodiagnostic AssayAbstractAntibodies to many pathogenic viruses can be detected in bloodserum and or salivaAmong theseare many arbovirusesthat share endemic regions in the western hemisphere and in other parts of theworldThese include the related flaviviruses yellow fever virusYFVdengue virusDENVZika virusZIKVand West Nile vir ...

Systemic lupus erythematosusSLEis a complex autoimmune disease with a broad spectrum of clinical manifestations that affect several organsSLE affects millions of individualswith women and minorities disproportionately burdenedand is associated with significant morbidity and mortalityDespite considerable progress made towards understanding the disease and the identification of the central roles pla ...

ABSTRACT Next generation sequencingNGShas the potential to revolutionize how infectious disease is diagnosed and treatedenabling the detection of a wide variety of pathogens in a single testHoweverdespite the increasing adoption of molecular diagnostics in clinical microbiology labsNGS has not become widespread due to its costturnaround timeand the technical and computational expertise required to ...