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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Point-of-care diagnostic test for T. cruzi (Chagas) infection

    SBC: KEPHERA DIAGNOSTICS LLC            Topic: NIAID

    Project Summary Chagas diseasecaused by infection with the parasite Trypanosoma cruziis the most prevalent parasitic disease in the western hemisphereinfectingmillion individuals and with overmillion at riskThe infection is transmitted by an insect vectorbut can also be acquired through blood transfusionorgan transplantor congenitallyFollowing a brief acute phasethe parasite persists for years in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Novel Indication for Myeloid Progenitor Use: Induction of Tolerance in Solid Organ Transplantation

    SBC: Cellerant Therapeutics, Inc.            Topic: NIAID

    PROJECT SUMMARY State of the art techniques result inyear solid organ graft loss ofto overin cardiopulmonary organ transplantationEstablishment of donor specific immunological toleranceDSITa condition in which a recipient accepts a transplant without immunosuppressionwhile retaining the ability to fight infectionswould reduce graft loss and transplant related complicationsThe only identified metho ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Real-time monitoring of inorganic chloramines near swimming pools

    SBC: SEACOAST SCIENCE, INC.            Topic: NCEZID

    Chlorination of swimming pools is necessary to insure swimmers healthhoweverthis process results in the formation of organic and inorganic chloraminesThe presence of volatile inorganic chloramines proximate to the water surface cause a variety of maladiesieirritation to the eyesskinand respiratory systemThe concentration of the chloramines tend to accumulate specifically in indoor poolsIn response ...

    SBIR Phase I 2018 Department of Health and Human ServicesCenters for Disease Control and Prevention
  4. A Customizable Real-Time Biosensor for Continuous Monitoring of Water Contaminants

    SBC: QUANTITATIVE BIOSCIENCES, INC.            Topic: NIEHS

    Ensuring access to clean water for generations to come will involve developing novel approaches to determining the safety and composition of potable water that are practical and affordableArsenicmercuryand cadmium are three of the top priorities among hazardous substances commonly found at Superfund sitesas they are linked to health problems in people exposed to them in drinking wateryet the curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Quorum:natural product discovery via mass spectrometry and molecular networking

    SBC: ABTERRA BIOSCIENCES, INC.            Topic: 400

    Project Summary Advances in genome miningand consequent realization of untapped microbial diversity has lead to renewed interest in natural productNPdiscoveryNPs are a rich source of therapeutic candidateswith a long history of successes in combating infectious diseasesand oncologyThe emergence of antibiotic resistant bacteria like Cdifficile and carbapenem resistant enterobacteiaceaeCREonly empha ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Preclinical development of an intravaginal ring for the sustained release of Pritelivir for the treatment and prophylaxis of Genital Herpes in women

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: NIAID

    SUMMARY The broadlong term goal of this project is to develop a pritelivir intravaginal ringIVRfor the treatment and pre exposure prophylaxis of genital herpesa common problem that affects more thanmillion AmericansRecurrences are common and may be painfulInfection is life longPritelivir is a promisinghelicase inhibitor that proved superior to existing therapies in Phaseclinical trialsbut whose cl ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Development of a Human Liver Microphysiological System For Alcoholic Liver Disease

    SBC: Emulate, Inc.            Topic: 500

    PROJECT SUMMARYAlcoholic liver diseaseALDincludes a broad range of progressive disease stagesfatty liveralcoholic steatohepatitisASHliver fibrosisliver cirrhosisand hepatocellular carcinomaIn spite of being one of the major causes of morbidity and mortality in the worldthere are currently no effective strategies that can preventtreat or monitor the progress of ALD owing primarily to lack of human ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Cerberus therapy for metastatic disease

    SBC: Talapo Therapeutics            Topic: 102

    Metastasis is the most common cause of cancer related mortalityyet there are currently no therapeutic options that can be used to stop the spread of malignant cellsRecentlytwo members of the Transforming Growth Factorfamilythe secreted ligands Nodal and Bone Morphogenetic ProteinBMPhave been linked with increased metastasis in breast and other cancersThese cytokines activate stem cell programs in ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Multiplexed single-cell contractility assay to develop therapeutics for asthma and hypertension

    SBC: FORCYTE BIOTECHNOLOGIES, INC.            Topic: 100

    SUMMARYABSTRACT Asthmatic bronchoconstriction and hypertensive vasoconstriction are extremely common disease states in which excessive contractile cellular forces directly contribute to the pathophysiologyExisting treatments for these diseaseswhich affectmillion andmillion Americansrespectivelyhave severe side effectsbecome desensitized over prolonged useor lack efficacy altogetherIn particularLAB ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Preclinical small animal imaging platform for detection and quantification of early metastasis

    SBC: PHOTOSOUND TECHNOLOGIES, INC.            Topic: 102

    SUMMARY Metastases of tumors are associated with more thanof cancer deathsDespite years of therapeutic developmentmortality has improved only incrementally by few months at bestThe preclinical development phase for modern metastatics currently misses critical quantitative information on metastatic progressionMulti point in vivo observation of early metastasis and quantitative assessment of its dev ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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