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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. High-throughput functional analysis and clinical relevance of all possible variants of a gene

    SBC: HELIGENICS, INC.            Topic: NHGRI

    Modern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Evaluating the efficacy of Butyric acid pro-drug nanoparticle in retinal neuroprotection

    SBC: Nutriforward, LLC            Topic: 100

    Project Summary Choroidal neovascularization (CNV) occurs in both age-related macular degeneration (AMD) and diabetic retinopathy (DR). While anti-VEGF treatment has improved the visual outcome considerably, they are far from achieving a 100% success rate (non-responsiveness between 8 and 50%). Inherited retinal degenerations (IRDs) are a group of heterogeneous, progressive, visually debilitating ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Quantitative Normalization of Spatial Metabolomics for Molecular Signatures of Tissue Heterogeneity

    SBC: SYGNAMAP INC            Topic: 400

    PROJECT SUMMARY The molecular and biochemical basis of tissue heterogeneity in normal and disease states can be addressed with spatial omic analysis. Advances in spatial metabolomic analysis of tissue biopsies using MALDI-MSI could enable the identification of numerous biochemical pathways as signatures of specific histopathology features. However, to extract the most robust disease- relevant biom ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. COPA, an Automated Medication Dispensing and Remote Management System for at Home Methadone Dispensing

    SBC: BERKSHIRE BIOMEDICAL CORPORATION            Topic: NIDA

    ABSTRACT Methadone maintenance reduces and/or eliminates the use of opioids, reduces the death rates and criminality associated with opioid use, and allows patients to improve their health and social productivity. In addition, enrollment in Methadone Maintenance Treatment (MMT) can reduce the transmission of infectious diseases associated with opioid injection, such as hepatitis and HIV. The Compu ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Developing a robust native extracellular matrix to improve islet function with attenuated immunogenicity for transplantation

    SBC: STEMBIOSYS, INC.            Topic: 200

    Project Summary/Abstract Compared to daily multiple insulin injections, pancreatic islet transplantation for type 1 diabetes (loss of β-cells) or the latter stages of type 2 diabetes (β-cells fail to produce sufficient insulin) provides a near physiologic regulation of normal blood glucose levels and significantly improves quality of life by minimizing severe hypoglycemia and diabetic complicati ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Far-Forward Austere Sterilizer (FAST)

    SBC: LYNNTECH INC.            Topic: DHA213006

    Sterilization of medical and surgical tools is a critical step in minimizing the risk of infection to combat casualties during far-forward medical interventions. However, there are significant challenges to providing sterile equipment in austere environments where power is limited and ability to transport equipment and deliver supplies is constrained. The complexity of modern surgical tools, such ...

    SBIR Phase II 2023 Department of DefenseDefense Health Agency
  7. Development of a Chemical Sterilant for Use in Austere Environments

    SBC: TDA RESEARCH, INC.            Topic: DHA213005

    The goal of this project is to develop and validate the performance of a chemical sterilant solution for use in austere environments that sterilizes surgical instruments and other materiel through immersion. The product is a concentrate that when mixed with potable water creates a solution capable of the desired sterilization. In Phase I, we identified formulations that quickly produce the chemica ...

    SBIR Phase II 2023 Department of DefenseDefense Health Agency
  8. Bougie-Integrated Endotracheal Intubation Stylet

    SBC: Olifant Medical, Inc.            Topic: DHA213004

    It is well established that difficulty and multiple attempts at endotracheal intubation (ETI) during emergency circumstances result in up to a 4-fold increase in complications, including cardiac arrest. In the tactical combat casualty care (TCCC) environment, ETI encompasses the majority of combat prehospital airway securement. Unfortunately, ETI is one of the most common incorrectly performed lif ...

    SBIR Phase II 2023 Department of DefenseDefense Health Agency
  9. Revisiting the Nasopharyngeal Airway (NPA): The Next-Level NPA

    SBC: Olifant Medical, Inc.            Topic: DHA213003

    Airway compromise continues to account for approximately 1 in 10 preventable battlefield deaths. Combat medics often provide care in no or low-light conditions, surrounded by the chaos of combat, and with the limited dexterity that accompanies bulky body armor, gloves, and heavy equipment. Far-forward medical care is also limited by available resources, which are often only what a combat medic can ...

    SBIR Phase II 2023 Department of DefenseDefense Health Agency
  10. SensiTrak: Automated Assessment of Forelimb Sensation

    SBC: VULINTUS, INC            Topic: NINDS

    Project Abstract Current common methods for measuring somatosensory function in preclinical rodent models generally rely on withdrawal responses to uncomfortable or painful stimuli. These tests can be stressful to the animal, while also yielding a high variability in measured responses, and repetitive testing in longitudinal models may even result in chronic pain states. To better understand the c ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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