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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A novel therapy for acute alcoholic hepatitis

    SBC: SEAL ROCK THERAPEUTICS, INC.            Topic: 999

    Each year approximately 5 million people in the US develop acute alcoholic hepatitis (AH), a syndrome of progressive inflammatory liver injury. In most patients with AH, the illness is mild. However, in patients with severe acute AH, risk of early death is high and intensive management is required with minimal pharmacological agents available. Seal Rock Therapeutics is developing SRT-015, a potent ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a first-in-class nonmuscle myosin II inhibitor to prevent substance use disorder relapse

    SBC: MYOSIN THERAPEUTICS INC.            Topic: NIDA

    PROJECT SUMMARY In 2018, over 1 million people in the U.S. qualified as having a methamphetamine (METH) use disorder and rates of METH use are surging, largely in response to the opioid epidemic. METH use disorder is a chronic condition for which there are currently no FDA-approved medications. The only treatment options available are behavioral modification therapies, which have limited efficacy, ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Enhancing the quality of CBT in community mental health through AI-generated fidelity feedback

    SBC: LYSSN.IO, INC            Topic: 104

    Each year, millions of Americans receive evidence-based psychotherapies (EBPs) such as cognitive behavioral therapy (CBT) for the treatment of mental and behavioral health problems. Yet, at present, there is no scalable method for evaluating the quality of psychotherapy services. In research settings, human-based behavioral coding methods are used, but these are time consuming, costly, and rarely ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Small Molecule for the Treatment of Periodontitis

    SBC: VIRTICI LLC            Topic: NIDCR

    Project Summary Our goal is to develop a first-in-class inhibitor of P. gingivalis colonization of oral biofilms as a treatment for periodontitis. Severe periodontitis affects more than 11% of the world's population, resulting in billions of dollars of direct and indirect costs to society, and is associated with a number of chronic conditions including autoimmune, cardiovascular, respiratory, and ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. An AI-based Multimodal Approach to Predict Pain in Postnatal Care Scenarios

    SBC: Stereology Resource Center, Inc            Topic: NICHD

    PROJECT SUMMARY Advances in technology and surgical procedures in the past decade have led to a remarkable increase in numbers of newborns subjected to lifesaving surgery. These postoperative neonates are customarily triaged to neonatal intensive care units (NICUs) for pain management with opioids, primarily morphine, fentanyl, and methadone. However, substantial evidence from in- vitro, animal, a ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. The Development and Systematic Evaluation of an AI-Assisted Just-in-Time-Adaptive-Intervention for Improving Child Mental Health

    SBC: Colliga Apps Corp.            Topic: NIMH

    PROJECT SUMMARY/ABSTRACT Early childhood mental health problems constitute a significant public health concern with wide-ranging impacts on functioning both concurrently and later in life. Although childhood mental health is influenced by a variety of factors, the quality of relationships with caregivers plays a critical role. Critical, coercive, and conflictual parent- child interactions have bee ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Improving Outcomes in Cancer Treatment-Related Cardiotoxicity

    SBC: LightSeed, Inc.            Topic: NHLBI

    Project Summary/Abstract Anthracyclines, such as Doxorubicin (DOX), are effective for the treatment of many cancers (Ovarian, Multiple Myeloma, Kaposi Sarcoma, Leukemia, Bone Sarcoma, Breast, Endometrial, Gastric, Liver, Kidney, and other Cancers). The global DOX market is increasing annually and expected to reach $1.3B by 2026. DOX toxicity is therefore relevant to a broad number of cancers. Howe ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. EaseAlert: Tactile Firefighter Alerting System Designed to Reduce Negative Cardiovascular Outcomes and Sleep Disturbances

    SBC: EASEALERT LLC            Topic: NHLBI

    Project Abstract Sudden cardiac death (SCD) has been the leading cause of on-duty death (ODD) in the fire service over the past several decades, accounting for 51.6% of all ODDs in 2019. The primary factors that contribute to SCD among firefighters are overexertion and stress, and SCD is most likely to occur during fire suppression and alarm response. When an emergency occurs, firefighters are ale ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment

    SBC: SPECTREE INC.            Topic: 143

    Project SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a lead candidate for the treatment of Alzheimer's disease

    SBC: Vova Ida, LLC            Topic: NIA

    SUMMARY Alzheimer’s disease (AD) is an age-related neurodegenerative disease that has become a global epidemic with over 40 million people affected worldwide and a projected 115 million in 2050. It is the 6th leading cause of death in the United States. AD has a tremendous impact on health, society and the economy. Approved treatments at best partially ameliorate some symptoms. There is an urgen ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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