Award Data

PROJECT SUMMARY/ABSTRACT The Radiopharmaceutical Therapy (RPT) market is projected to surpass the Technitium-99m market by 2025, with an emphasis on metastatic prostate cancer, neuroendocrine tumors, and lymphoma. Driven by well- tolerated treatments and fewer side-effects, experts have estimated 150 new theranostic centers will be needed in the U.S. to deliver an estimated 50,000–200,000 treatm ...

Project Summary/Abstract Every year, 150,000 Americans are affected by Acute Respiratory Distress Syndrome (ARDS), an inflammatory lung condition that may complicate severe pneumonia (including influenza and COVID-19), trauma, sepsis, cancer, and many other conditions. The mortality of ARDS is 27%, 32%, and 45% for mild, moderate, and severe disease, respectively. The survival rate for COVID-19 pa ...

Gadolinium (Gd)-based MRI contrast agents (GBCAs) are used in clinical magnetic resonance imaging (MRI) for cancer detection and staging, particularly of primary and metastatic brain cancers. However, there are concerns about the potential long-term toxicity of GBCAs. GBCAs cause nephrogenic systemic fibrosis (NSF), a devastating disorder that affects patients with kidney disease. FDA imposed a †...

Project Summary The goal of the project proposed is to develop a gas chromatography and differential mobility spectrometry (GC/DMS) molecular identification library for volatile organic compounds (VOCs) using a deep neural network approach. Vox Biomedical scientists will test the hypothesis that a novel, multi-task neural network architecture can predict characteristics of an previously unseen ana ...

Abstract/Summary The goals of this SBIR Phase I grant are: (1) to use the clinically compatible FL118 product to perform the non- good laboratory practice (GLP) and GLP toxicology (TOX) and toxicokinetics (TK) studies; and (2) to author and file the FL118 Investigational New Drug (IND) application with the FDA for first-in-human FL118 phase 1 clinical trials in patients with advanced pancreatic du ...

PROJECT SUMMARY Substance use disorder (SUD) is a significant public health challenge, and it has been estimated that its effects on healthcare, work productivity, and criminal justice costs the US over $600 billion annually. Engagement with the clinical care team is critical to an individual’s path to SUD recovery; however, limited capacity of and access to addiction treatment providers and tra ...

PROJECT SUMMARY Bloomer Tech is advancing development of the Bloomer Augmented Garment Platform, a wearable bra with embedded sensors to address cardiovascular healthcare disparities in women. Cardiovascular disease is the leading cause of death in women, resulting in nearly 315,000 deaths in the U.S. in 2020, where women generally experience worse outcomes than men including increased disability, ...

PROJECT SUMMARYMajor depressive disorder (MDD) is a serious, debilitating, and often recurring disorder with a substantial lifetime risk and a high societal cost. Depressed patients frequently display a variety of co-morbid symptoms, including depressed moods, loss of motivation and/or reductions in the ability to experience pleasure (anhedonia), loss of interest and energy, combined with psycholo ...

PROJECT SUMMARYNonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease. One-fourth of the adult population suffers from NAFLD worldwide. Nonalcoholic steatohepatitis (NASH), the aggressive form of NAFLD, can progress to cirrhosis and hepatocellular cancer (HCC) and is rapidly becoming the leading cause of end-stage liver disease and liver transplantation. Liver fibrosi ...

Whole-brain mapping at the cellular and subcellular levels is crucial to systematically understand brain functions and disorders. Recent developments in tissue transformation techniques, such as CLARITY, SHIELD, MAP, ExM, CUBIC, and DISCO-based methods, have made significant progress towards whole-organ molecular labeling and microscopic imaging by rendering intact tissue chemically permeable and ...