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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. New Cell Reprogramming Technology to Produce Dopaminergic Neurons

    SBC: Cell Reprogramming & Therapeutics LLC            Topic: NIA

    DESCRIPTION provided by applicant Cell Reprogramming andamp Therapeutics LLC will develop new cellular reprogramming technology to produce cell therapeutic product for the treatment of Parkinsonandapos s disease PD Advances in cell reprogramming technologies to generate patient specific cells of a desired type will revolutionize the field of regenerative medicine Over the lat decades sever ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Engineered Tissue Based Phenotypic Screening of Mixture based Libraries

    SBC: INVIVOSCIENCES, INC.            Topic: NIA

    DESCRIPTION provided by applicant We propose to demonstrate the strength of combining our engineered tissue based drug screening approach and a systematically organized mixture based chemical library This approach could become an ultimate tool to develop treatments for complex diseases such as cardiac fibrosis without known drug targets initially Heart failure is the most common cause of ho ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Lentiviral Vector for the treatment of Fanconi Anemia

    SBC: Rimedion, Inc.            Topic: NHLBI

    DESCRIPTIONprovided by applicantIn this Phase II STTR application Rimedion seeks to commercialize a novel treatment for patients suffering from Fanconi anemia and request funding for a Phase I II clinical trialThe product will utilize a HIVbased lentiviral vector expressin the Fanconi anemia A proteinThe strong scientific support for this approached is strengthened by a successful Phase I STTRThe ...

    STTR Phase II 2015 Department of Health and Human Services
  4. Noom Monitor for Binge Eating

    SBC: Noom, Inc.            Topic: 104

    DESCRIPTION provided by applicant Binge eating is a core maladaptive behavior characteristic of several forms of eating pathology including bulimia nervosa BN and binge eating disorder BED These chronic conditions affect approximately percent of the population and cause significant psychosocial and physical impairment However a number of barriers prevent the implementation of effecti ...

    STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  5. High Frequency Acceleration to Restore Alveolar Bone

    SBC: Propel Orthodontics, LLC            Topic: NIDCR

    DESCRIPTION provided by applicant The health of the oral cavity depends on the alveolar bone which may be compromised by loss of morphology decrease in height width or decreased density Treatments for alveolar bone loss are the application of bone grafts and placement of implants Only a small percentage of population is able to afford treatment This suggests the majority of the populatio ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Point-of-Care Spliced RNA Diagnostic for Oral Detection of Replication-Competent Latent HIV-1 Infection

    SBC: Jan Biotech, Inc.            Topic: NIDCR

    DESCRIPTION provided by applicant In the CDC estimated well over million people over age are living with HIV infection with over others infected but undiagnosed Strict adherence to highly active combination anti retroviral therapy HAART cART persist despite prevents full blown AIDS but fails to prevent complications from latent HIV reservoirs that treatment In particula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. A Microfluidic System for POC Molecular Diagnosis of HPV in Oral Fluids

    SBC: LUCIGEN CORPORATION            Topic: NIDCR

    DESCRIPTION provided by applicant The human Papilloma Virus HPV causes a wide variety of diseases in humans including squamous papilloma focal epithelial hyperplasia verruca vulgaris and condyloma acuminatum In addition to benign diseases HPV infection is implicated as an etiologic agent in malignancies including cervical and anogenital cancer HPV has been identified as the most commo ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Ultrasound Imaging of Breast by Use of a Hemispheric Array and Inverse Scattering

    SBC: HABICO, Inc.            Topic: 102

    DESCRIPTION provided by applicant The long term objectives of this project are to develop a high performance cost effective clinical prototype of a unique breast imaging system HABIS that uses non ionizing ultrasound for examination of the breast and to demonstrate the medical value and clinical efficacy of the system through trials of the system in medical center and outpatient imaging cent ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Development of an automated Umbilical Cord Blood Hematopoietic Stem Cell expansion by endothelial cells for transplantation

    SBC: Angiocrine Bioscience            Topic: NCI

    DESCRIPTION provided by applicant Initially umbilical cord blood UCB transplantation was limited to children given the low cell dose infused Both related and unrelated cord blood transplants have been performed with high rates of success for a variety of hematologic disorders and metabolic diseases in the pediatric setting In more recent years the use of UCB transplants has expanded and r ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Expressive Speech Synthesis for Speech-Generating Devices

    SBC: SYNFONICA LLC            Topic: NIDCD

    DESCRIPTION provided by applicant The ability to express emotion through speech is an essential element of human communication yet individuals with speech impairments who rely on speech generating devices to communicate are often deprived of this ability Current speech generating devices offer at most a limited number of expressive speech modes e g a andquot happyandquot voice or a andquo ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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