Award Data

This broader impact/commercial potential of this STTR Phase I project is to address certain medical procedures, such as percutaneous nephrolithotomy (PCNL). Currently, one in 11 people develop kidney stones by the age of 70, with a lifetime recurrence rate of 60-80%. PCNL, which involves removal of kidney stones through a surgical channel into the kidney, is the preferred method for stones less th ...

Abstract Factors that contribute to the onset of inflammatory bowel disease (IBD) remain incompletely understood. Although specific genetic factors may increase risk, most IBD cannot be readily explained based on genetics. Dysbiosis in intestinal microbiomes also has been implicated. Once IBD is established, chronic inflammation is a central hallmark and also a major target for therapy. Both forms ...

Because of the maneuvering capabilities of adversaries’ new hypersonic weapons, defensive missiles must fly in very demanding flight regimes, and intercept maneuvers place stringent requirements on interceptor seeker systems. Successfully completing the hit-to-kill end game requires the seeker can either compensate for or perform despite the thermal and optical effects that cause the seeker to m ...

Exciting Technology, LLC (ET) and University of Dayton Research Institute (UDRI) along with their Transition partner Lockheed Martin Coherent Technologies (LMCT) plan to extend the Phase I phenomenology and wave optics simulations, and build a vibration imaging LiDAR for target phenomenology characterizations in controlled environments.  In addition, the team provides an optional path to accelera ...

SUMMARYIn 2014 the United States experienced an outbreak of a previously unknown neurological disease with polio-like symptoms later known as acute flaccid myelitis (AFM). A biennial surge in cases of AFM in 2016 and 2018 has alarmed public health officials. Since then, rapidly accumulating clinical, immunological, and epidemiological evidence has pointed to EV-D68 as the major causative agent of ...

PROJECT SUMMARY/ABSTRACT The recent groundbreaking experiment using a single neutralizing monoclonal antibody (nmAb) to reduce the death rate in Ebola virus (EBOV)-infected individuals highlights the importance of this class of drug in the treatment of infectious disease. In August 2019, Dr. Anthony Fauci announced that administration of mAb114 had reduced the death rate from 70% to approximately ...

Arthropod-borne viruses (arboviruses) present a substantial threat to human and animal health worldwide. They are transmitted by hematophagous arthropods, in which mosquitoes are one of the main transmitters. The mosquito specie, Aedes aegypti, is the primary mosquito vector of several widely spread arboviruses as zika, dengue or West Nile viruses. Mosquitoes transmit these pathogens by inoculatin ...

Lyme disease (LD) is the most prevalent vector-borne disease in the United States, with up to 300,000 cases a year. LD is caused by several species of the spirochete bacteria Borrelia burgdorferi sensu lato (the Lyme borreliae), which are transmitted by ticks from animal (bird, rodent) reservoirs to human hosts. While a short course of antibiotics is usually effective in eliminating the bacteria a ...

Mounting of infrared (IR) windows on hypersonic vehicles is a critical design issue because of the stresses caused by high temperatures combined with the coefficient of thermal expansion (CTE) mismatch between the window and frame materials. Many applications use elastomeric seals to limit window distortion and stress by allowing for joint flexibility. However, windows and frames operating in this ...

The broader/commercial impact of this Small Business Technology Transfer (STTR) Phase I project is to address age-related cognitive impairments. Neurodegenerative disorders are a rapidly growing public-health concern, with Alzheimer’s disease alone projected to affect 13.8 million Americans by 2050. Alzheimer’s disease patients undergo gradual cognitive decline and during this progression, pat ...