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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Dehydrogenase Crystals as Catalysts in Organic Synthesis

    SBC: ALTUS BIOLOGICS, INC.            Topic: N/A

    Enzyme microcrystals (less than 100 um) grown from aqueous solution and cross-linked witha bifunctional agent such as glutaraldehyde exhibit remarkable characteristics that are superior to bothsoluble and conventionally immobilized enzymes. Such cross-linked enzyme crystals (CLECs) remainactive in environments that are otherwise incompatible with enzyme function, including prolongedexposure to hig ...

    SBIR Phase II 1996 Department of Health and Human Services
  2. Dehydrogenase Crystals as Catalysts in Organic Synthesis

    SBC: ALTUS BIOLOGICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 1994 Department of Health and Human Services
  3. PHOTOCLEAVABLE TAGS FOR MANIPULATION OF DNA/RNA

    SBC: AMBERGEN, INC            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  4. Improved Isolation of Marine Natural Products

    SBC: APHIOS CORPORATION            Topic: N/A

    The overall goal of this R&D program is to develop improved methodologies and manufacturingprocesses for the isolation of marine natural products with anticancer or anti-HIV activity. Thetherapeutic potential of marine natural products has rapidly advanced in recent years. One suchpotential therapeutic is bryostatin I which is derived from the marine bryozoan Bugula neritana. Whileharvesting the b ...

    SBIR Phase I 1994 Department of Health and Human Services
  5. Supercritical Fluid Extraction of Michellamine B

    SBC: APHIOS CORPORATION            Topic: N/A

    Michellamine B is a potential anti-HIV agent isolated from the leaves of a Cameroonian vine,Ancistrocladus korupensis, which grows in the Korup region of Cameroon. Preclinical testing ofMichellamine B by the National Cancer Institute may be adversely impacted by raw materials availability,and the inefficiencies of conventional, large-scale manufacturing processes. The latter is time, labor andmate ...

    SBIR Phase II 1996 Department of Health and Human Services
  6. Fluorophore Labeled Nucleic Acid Probes

    SBC: APHIOS CORPORATION            Topic: N/A

    This investigation is aimed at devising ways and special instrumentation for using fluorescentlanthanide chelates, detected by time resolved fluorometry, as a means for detecting nucleic acids in avariety of settings such as Southern blots and cells or tissues (e.g., as in situ hybridization). Thesemethodologies have the potential of high sensitivity, since time-resolved fluorometry permits detect ...

    SBIR Phase I 1994 Department of Health and Human Services
  7. Supercritical Fluid Extraction of Michellamine B

    SBC: APHIOS CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1994 Department of Health and Human Services
  8. DEVELOPMENT OF A VIRUS FREE FIBRIN GLUE

    SBC: APHIOS CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  9. SPEECH RECOGNITION FOR AUTOMATING TELEPHONE INTERVIEWS

    SBC: Applied Language Technologies            Topic: N/A

    N/A

    SBIR Phase I 1996 Department of Health and Human Services
  10. Semiautomatic, Quantitative Analysis of Funds

    SBC: APPLIED SCIENCES LABORATORY, INC.            Topic: N/A

    N/A

    SBIR Phase II 1996 Department of Health and Human Services

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