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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IDENTIFICATION OF GENETIC LESIONS LEADING TO MUTATIONS

    SBC: STRATAGENE            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  2. MONOCLONAL ANTIBODY TEST KIT FOR CAMPYLOBACTER

    SBC: Synbiotics Corpon            Topic: N/A

    ACUTE GASTROENTERITIS MAY BE THE SECOND MOST COMMON ILLNESS IN HUMANS, WITH CAMPYLOBACTER AMONG THE MOST IMPORTANT CAUSATIVE AGENTS. WORLDWIDE, THERE ARE A BILLION CASES OF DIARRHEA ANNUALLY AND SEVERAL MILLION DEATHS. THERE ARE NO LICENSED OR WIDELY USED RAPID DIAGNOSTIC METHODS AVAILABLE TO IDENTIFY CAMPYLOBACTER INFECTION. WHEN USED, THE STOOL CULTURE IS ARGUABLY THE MOST UNTIMELY AND COST INEF ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. MONOCLONAL ANTIBODY TEST KIT FOR ROTAVIRUS

    SBC: Synbiotics Corpon            Topic: N/A

    ACUTE GASTROENTERITIS IS ONE OF THE MOST COMMON AFFLICTIONS IN HUMANS, WITH HUMAN ROTAVIRUSES AMONG THE MOST IMPORTANT CAUSATIVE AGENTS. THESE PATHOGENS ACCOUNT FOR 40 TO 60 PERCENT OF THE DIAGNOSED CASES OF PEDIATRIC (UNDER AGE 2) GASTROENTERITIS AND ARE THE SINGLE MOST IMPORTANT ETIOLOGIC AGENT FOR ACUTE GASTROENTERITIS IN THE DEVELOPED COUNTRIES. IN THE LESS DEVELOPED COUNTRIES, ROTAVIRUS IS TH ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. NEW METHODS FOR SYNTHESIS OF FLUORESCENT DNA

    SBC: SYNTHETIC GENETICS, INC.            Topic: N/A

    THE GOAL OF THIS RESEARCH IS TO DEVELOP REAGENTS AND METHODSFOR THE DIRECT CHEMICAL SYNTHESIS OF FLUORESCENT DNAS DESTINED FOR USE AS DNA HYBRIDIZATION PROBES AND IN PRIMER-DIRECTED DNA SEQUENCING. RECENTLY, HOOD AND COWORKERS HAVE DEVELOPED A PRIMER-DIRECTED DNA SEQUENCING TECHNIQUE. DNA PROBES HAVE ALSO BEEN FOUND TO BE USEFUL FORDETECTING BACTERIA AND VIRUSES AS WELL AS GENETIC ABNORMALITIES. S ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. IMPROVED REAGENTS FOR SYPHILIS DIAGNOSIS

    SBC: Syntro Corp.            Topic: N/A

    A PROJECT TO DEVELOP A STATE-OF-THE-ART SERODIAGNOSTIC ASSAY FOR SYPHILIS WITH RECOMBINANT TREPONEMA PALLIDUM ANTIGENS IS PROPOSED. THE DEVELOPMENT OF RECOMBINANT DNA-DERIVED REAGENTS WOULD BE OF GREAT BENEFIT TO THE PUBLICHEALTH AGENCIES, CLINICAL LABS, HOSPITAL, AND BLOOD BANKS THAT CONDUCT SERODIAGNOSTIC TESTS FOR SYPHILIS BY IMPROVING ACCURACY AND LOWERING THE COSTS OF TESTING. THE ANTIGENS WO ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. DEVELOPMENT OF A HIGHLY COMPLIANT VASCULAR GRAFT

    SBC: Thoratec Laboratories Corp            Topic: N/A

    A NEW, HIGHLY COMPLIANT VASCULAR GRAFT FABRICATED FROM A UNIQUE POLYURETHANE MATERIAL WILL BE DEVELOPED AND TESTED. THE BULK AND SURFACE PROPERTIES REQUIRED OF THIS MATERIAL HAVE BEEN DECOUPLED AND DEVELOPED INDEPENDENTLY IN TWO SEPARATE MATERIALS. THE FINAL POLYMER WILL POSSESS OVERALL OPTIMIZED CHARACTERISTICS BY BLENDING OPTIMIZED SURFACE ACTIVE COPOLYMERS INTO THE OPTIMIZED BULK MATERIAL. USIN ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. ELECTRICAL BRAILLE PAGE OUTPUT DEVICE USING NITINOL SMA

    SBC: Tini Alloy Company            Topic: N/A

    THE OBJECTIVE OF THIS RESEARCH IS A PAGE-FORMAT, ELECTRONIC-ALLY CONTROLLED BRAILE OUTPUT DEVICE FOR BLIND COMPUTER USERS. EACH DOT, SIX OF WHICH CONSTITUTE A BRAILLE CHARAC- TER, IS ACTUATED BY A SHORT LENGTH OF FINE-GAUGE WIRE. THE WIRE IS MADE OF A SHAPE-MEMORY ALLOY: NITINOL. THIS METHODHAS PROVEN FEASIBLE FOR A SINGLE DOT. FURTHER RESEARCH WILLCOMBINE SIX DOTS INTO A STANDARD-SIZE BRAILLE CHA ...

    SBIR Phase II 1987 Department of Health and Human Services
  8. EXPANDABLE LASERPROBE FOR TREATMENT OF CORONARY DISEASE

    SBC: Trimedyne, Inc.            Topic: N/A

    THE SPECIFIC AIM OF THIS PROJECT IS TO DESIGN, CONSTRUCT, AND EVALUATE IN ANIMALS AN EXPANDABLE LASERPROBE FOR TREATMENT OF OCCLUSIVE CORONARY AND PERIPHERAL ARTERY DISEASE. THE PROPOSED DEVICE PROVIDES MEANS FOR CONTROLLED APPLICATION OF HEAT AND PRESSURE TO ATHEROSCLEROTIC TISSUE. THE PRINCIPLE OF OPERATION INVOLVES THE TRANSMISSION OF LASER ENERGY FROM SOURCE TO PATIENT AND THE RAPID CONVERSION ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. LIPOSOME-ENCAPSULATED B-10 FOR NEUTRON CAPTURE THERAPY

    SBC: Vestar, Inc.            Topic: N/A

    NEUTRON CAPTURE THERAPY IS AN ATTRACTIVE ALTERNATIVE TO STANDARD RADIATION TECHNIQUES FOR CANCER TREATMENT IF NUCLEI, SUCH AS (10)B, CAN BE SELECTIVELY CONCENTRATED IN TUMORS. SMALL, UNILAMELLAR, PHOSPHOLIPID VESICLES ARE KNOWN TO BE TAKEN UP BY ANIMAL AND HUMAN TUMORS. LIPOSOME FORMULATIONS WILL BE TESTED FOR THEIR ABILITY TO ENCAPSULATEHIGH CONCENTRATIONS OF BORON COMPOUNDS IN A STABLE MANNER. B ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. TONGUE ACTIVATED COMPUTER CONTROL FOR THE HANDICAPPED

    SBC: Zofcom Inc            Topic: N/A

    DEVELOPMENT OF A TONGUE ACTIVATED CONTROLLER WILL PERMIT HIGH LEVEL PARAPLEGICS AND QUADRAPLEGICS RAPID, VOICE INDEPENDENT COMPUTER INPUT AND DEVICE CONTROL. SINCE TONGUE FUNCTION CLOSELY RESEMBLES THE FINGERS IN SENSITIVITY, QUICKNESS AND SPACIAL AWARENESS, THE TONGUE IS AN IDEAL MEANS OF COMMUNICATION. OUR GOAL IS TO DESIGN AND CONSTRUCT A TONGUE CONTROLLED DEVICE AND TO INTERFACE THIS DEVICE TO ...

    SBIR Phase II 1987 Department of Health and Human Services

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