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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Anchors Away: A Family-Focused CBT Skills App (Anchors App)

    SBC: VIRTUALLY BETTER INC            Topic: 104

    PROJECT ABSTRACT Anxiety disorders are among the most common psychological disorders with prevalent onset in early to midchildhoodRisk factors for childhood anxiety include behavioral inhibitionparental negative affect and parenting stressalong with parental anxiety levelswhich appear to moderate both symptom onset and improvementWhile cognitive behavioral therapyCBTis considered the first line tr ...

    SBIR Phase II 2017 Department of Health and Human Services
  2. Development of Novel Adenosine Polymers for Coating Medical Devices

    SBC: ADENOPAINT LLC            Topic: NHLBI

    Project SummaryMyocardial infarctionMIoccurs inAmericans annually accounting for a mortality ofWhile percutaneous coronary interventionPCIis invariably successful in restoring epicardial patencysignificant microvascular obstructionMVOresulting in theno reflow phenomenonNRFoccurs frequently which significantly impacts mortality and the development of CHFCurrent devices are only partially effective ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Development of Chemistry, Manufacturing, and Control Standards for PGC and PGC-dANP

    SBC: PharmaIN Corporation            Topic: NHLBI

    ABSTRACTThis application is seeking funding specifically for ChemistryManufacturingand ControlCMCof scale up production of long acting atrial natriuretic peptidedANPand its protected graft co polymerPGCexcipient for use in heart failureHFtreatmentThe extrinsic merit of this project will be the availability of cGMP grade PGC for use in prolonging the half life of various peptide drugs that are in p ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Advanced technology for the improvement of Modular Emergency Radiological Response Transportation Training

    SBC: Janus Research Group, LLC            Topic: NIEHS

    Abstract Summary JANUS Research Group proposes to develop a mixed reality technology solution that will provide individual and small group training that makes use of mobile platforms such as smartphones and tablets to support e learning of health and safety issues related to hazardous radiological material for first responders Our proposed approach leverages the capabilities of modern mobile de ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. SINGLE DOMAIN ANTIBODIES FOR DETECTION AND IMAGING OF MODIFIED RNA NUCLEOSIDES

    SBC: Vitan-Biotech LLC            Topic: NCI

    RNAs contain a wide variety of post transcriptional nucleoside modifications which play important roles in modulating RNA functions and are linked to various human diseases To decipher the functions of RNA modifications robust analytical tools that enable scientists to detect monitor and map RNA modifications are highly needed Unfortunately due to in vivo instability of RNAs and their non i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. DEVELOPMENT OF MEMBRANE ANCHORED CYTOKINES AS NOVEL VACCINE ADJUVANTS FOR THE ELDERLY

    SBC: METACLIPSE THERAPEUTICS CORPORATION            Topic: NIAID

    The contractor will use engineered versions of IL and GM CSF as adjuvants The engineered version of IL and GM CSF include a glycosyl phosphatidylinositol GPI anchor at the carboxyl terminal which permits their incorporation into lipid bilayers such as influenza viral like particles VLP The development of the adjuvant will be in the context of influenza in elderly populations The sp ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. CLONOGENIC HIGH THROUGHPUT ASSSAY FOR SCREENING RADIATION MODULATORS

    SBC: SuviCa, Inc.            Topic: NCI

    Clonogneic assays measure the ability of single cells to proliferate and form a colony This process approximates closely the regrowth and recurance of tumors after treatment with radiation or chemotherapy providing a ready assay to screen for drugs that block this process Yet clonogenic assays are laborintensive and too cumbersome for high throughout screening HTS of compound libraries Here ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A high-throughput sample preparation platform for genomic and epigenetic analysis

    SBC: Matchstick Technologies Inc.            Topic: 400

    Several types of cancerse gpancreatic and brain malignanciesremain extremely lethal despite the introduction of chemotherapy more thanyears agoThe hallmark of all cancers are somatic mutations which cannot be correctedIn sharp contrastepigenetic changesessential contributors to tumorigenesisare pharmacologically reversibleThe ability to remedy detrimental epigenetic alterations are opening up new ...

    SBIR Phase II 2017 Department of Health and Human Services
  9. Scientific Merit and Feasibility of Fructokinase Inhibition for Obesity

    SBC: Colorado Research Partners LLC            Topic: NIDDK

    Our goal is to develop a firstin class therapeutic agent that directly blocks the metabolism of fructosea key component in sugarIntake of sugarsucroseand high fructose corn syrupHFCSinduces metabolic syndrome and diabetes in laboratory animals and are strongly associated with obesity and diabetes in humansBoth sucrose and HFCS contain fructosewhich stimulates food intake by inducing leptin resista ...

    STTR Phase II 2017 Department of Health and Human Services

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