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Use of Highly Porous Polymer Beads to Remove Anti-A and Anti-B Antibodies from Plasma for TransfusionSBC: CYTOSORBENTS MEDICAL INC Topic: DHP15B001
The ready availability of universal donor plasma to rapidly treat massively bleeding hospital trauma patients and warfighters with combat casualties is a key element of current recommendations for trauma resuscitation, yet universal AB donor plasma is relSTTR Phase I 2016 Department of DefenseDefense Health Agency
SBC: ARIMA GENOMICS, INC. Topic: 172
DESCRIPTION provided by applicant Phenomenal advances in DNA sequencing technologies have enabled systematic identification of genetic variants in human individuals and the recent FDA marketing authorization of the first next generation genome sequencer signals the arrival of a new era of pharmacogenomics and personalized medicine Nevertheless DNA sequencing alone fails to provide complete i ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: VITALEX BIOSCIENCES LLC Topic: NIAID
DESCRIPTION provided by applicant Mucormycosis most commonly caused by Rhizopus oryzae is a life threatening infection that occurs in patients immunocompromised by diabetic ketoacidosis DKA neutropenia corticosteroid use and or increased serum iron Because of the rising prevalence of these risk factors the incidence of mucormycosis has risen Despite disfiguring surgery and aggressive ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: POLARONYX INC Topic: DHP15B002
Based on our success in developing the world first commercial high energy femtosecond fiber laser system and our leading proprietary technology development in ultrashort pulsed fiber laser material processing, PolarOnyx proposes, for the first time, a compact high energy fiber laser based smart wound healing tool to meet with the requirement of this DHP solicitation. It includes a high energy fs f ...STTR Phase I 2016 Department of DefenseDefense Health Agency
SBC: NEONC TECHNOLOGIES INC Topic: BT
DESCRIPTION provided by applicant Glioblastoma multiforme GBM the most common and malignant of all gliomas has a median survival time of months Standard of care chemotherapy using temozolomide TMZ is effective initially but the GBM inevitably recurs and these recurrent tumors are resistant to TMZ There are currently no effective treatment options for patients with TMZ resistant ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: LENIMA FIELD DIAGNOSTICS LLC Topic: R
DESCRIPTION provided by applicant Hepatitis B HB and hepatitis C HC are two of the most widespread infections worldwide caused by the blood borne HB virus HBV and HC virus HCV respectively About million and million people suffer from chronic HB CHB and chronic HC CHC respectively while about and people die each year due to the consequence of HB and ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: Schell Games LLC Topic: NICHD
DESCRIPTION provided by applicant HIV disproportionately impacts minority adolescents and most of them have neither undergone HIV testing and counseling HTC nor know their status Adolescence is a andquot window of opportunityandquot to intervene with HIV behavior change interventions Challenges to implementing and disseminating some effective HIV prevention programs in adolescents may lim ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: PROTEIN METRICS INC Topic: 400
DESCRIPTION provided by applicant Mass spectrometry has become a method of choice for identifying and characterizing small quantities of proteins in complex mixtures However the ability to perform the identification in a high throughput fashion has depended on the availability of high quality protein sequence databases This means that proteins from organisms with unsequenced or poorly sequen ...STTR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: AFASCI INC Topic: N
DESCRIPTION provided by applicant Preclinical evaluation of treatment strategies for retinal neurodegenerative diseases is highly dependent on mouse models Classical methods to assess the visual function of animals such as electroretinogram ERG which measures electrical responses in the retina do not address connections between the eye and brain or visual perception by the visual system ...STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
SBC: AFASCI INC Topic: NIDA
DESCRIPTION provided by applicant The abuse of illicit drugs such as cocaine marijuana and heroin remains a critical public health concern throughout the country and is associated with staggering economic and social consequences Cocaine remains the most frequently recorded illicit drug in emergency hospital visits and the leading cause of drug related deaths in the United States Since as hi ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health