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SBC: Novici Biotech LLC Topic: NHLBI
DESCRIPTION provided by applicant Fibroproliferative illnesses leading to organ fibrosis and failure are responsible for approximately of deaths in developed countries whether idiopathic triggered by environmental factors infections or genetics organ fibrosis results in significant morbidity and mortality Organ fibrosis is responsible for health care costs exceeding $ billion year ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: PROFUSA, INC. Topic: NHLBI
DESCRIPTION provided by applicant Continuous biochemical monitoring has the power to change currently accepted standards of care shifting the emphasis from treating illness to maintaining health Point in time snapshots of a patientandapos s health can miss critical fluctuations or early warning signs that might warrant early interventions or changes in disease treatment and management PROFUS ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: iXpressGenes, Inc. Topic: 100
Project Summary Crystallization followed by subsequent structure determination is a major step in understanding the structure function relationship of macromolecules Understanding macromolecule structure has become a key part in the development of new pharmaceuticals and is a major area of NIH research Crystallization however is also the rate limiting step despite technological efforts to a ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: SIGNAL SOLUTIONS, LLC Topic: NHLBI
ABSTRACTSignal Solutions has developed a novelnoninvasive and automated piezoelectric based sleep detection system for high throughput studies of sleep in miceand has recently expanded to rat studies as wellThe respiratory signal detected by the piezo sensor during sleep can be applied to investigate important health conditions including respiratory depression due to disease or drug useand other s ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: SERPLUS TECHNOLOGY LLC Topic: NIAID
PROJECT SUMMARY Asthma exacerbations are a major cause of ER visits and hospitalizations with annual direct costs of approximately $billionyear in the USAViral infectionsin particular rhinoviralRVinfectionsare a major precipitant of asthma exacerbations in allergic asthmaticsAs there are overRV serotypes andfor nowno RV vaccinenovel strategies to inhibit RV induced airway inflammation are needed t ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Chronic intrapulmonary delivery of a novel small molecule Wnt/beta-catenin inhibitor for Idiopathic Pulmonary FibrosisSBC: BETA CAT PHARMACEUTICALS, INC. Topic: NHLBI
Project Summary Idiopathic pulmonary fibrosisIPFis a devastatingprogressive disease with no known cure and no treatment that convincingly alters the disease course or significantly improves mortalityThe objective of this proposal is the development of nebulized delivery of the small molecule inhibitor of Wntcatenin signalingBCfor Idiopathic Pulmonary FibrosisPre clinical studies in rodentsdogsand ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: IntraVascular Imaging, Inc. Topic: NHLBI
The goal of this Phase I STTR project is to constructoptimizeand test a clinically viable intravascular near infrared fluorescence intravascular ultrasoundNIRF IVUSimaging catheter for simultaneous molecular and structural diagnosis of coronary artery diseaseCADCAD is a worldwide leading cause of death and disabilityincluding acute myocardial infarctioncongestive heart failureand sudden cardiac de ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: KLEIN BUENDEL, INC. Topic: NIA
The United States has the highest rate of incarceration in the world There are over state and federal prisons housing over million prisoners in the United States The demographics of the prison population are shifting Longer sentences and constrained options for early release compound this trend The older adult segment of prison populations has more than tripled since The health ...STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
SBC: Nido Surgical, Inc Topic: NHLBI
DESCRIPTIONprovided by applicantThe goal of this Fast Track STTR project is to develop a novel CardioPortTM surgical device that will enable minimally invasive beating heart repair without use of cardiopulmonary bypassCPBThere is a critical unmet need for new instruments to improve the surgical repair of heart defects in childrenCurrent best surgical practices involve either open heart surgery wit ...STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
Formation and Structural Property Relationships of a Tetracalcium Phosphate Bone Adhesive BiomaterialSBC: RevBio, Inc Topic: NIA
Project Abstract Approximatelyof all fractures occur in the small bones of the wristshands and feetamounting to more thanmillion annuallyConsidering functional losses associated with the locations of these injuriesproper reduction and fixation is critical to ensure optimal rehabilitation and recoveryComplex injuries that include irreducible fractures or segmental bone loss require operative fixati ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health