Award Data

DESCRIPTION (provided by applicant): Our proposal describes an elegant device called the Bumps that quantifies touch sensation on the fingers at low micron levels. The objectives are to diagnose peripheral neuropathy near its onset, when the possibility for reversal is highest, and to monitor either progression or reversal of neuropathy during treatment. Target neuropathies are those related to ch ...

Solid State Drives (SSDs) are emerging as attractive alternatives to traditional HDDs due to there reduced power consumption and potential for increased performance. SSDs have the potential to improve the performance of both Checkpoint Restart (CPR) and the Metadata Server (MDS) for high performance File Systems, e.g., Lustre. However, the write performance of SSDs is relatively poor (compared to ...

Energy consumption is quickly becoming one of the primary bottlenecks of compute clusters and supercomputers. The DOE is a primary developer and consumer of these power hungry supercomputers, however smaller cluster machines are also widely used through other government agencies and industries. Yet, there are few power profiling tools that allow application developers transparent insight into the ...

Currently the commercially available technologies for H2 separation such as pressure swing adsorption and cryogenic distillation are very energy intensive. Membrane technologies can be very energy efficient; but for high selective membranes low flux and high cost are the major challenges that frustrate commercialization. Recently, cermet has shown promise because of less precious metal usage and m ...

Higher operating temperature for the gas turbine engine is needed for enhanced efficiency, lower emission and increased performance goal. The current state-of-the-art thermal barrier coatings (TBCs) are not adequate to provide the needed protection for the metallic components of the turbine engine operating at higher TBC surface temperature (>1300

This Small Business Innovation Research (SBIR) Phase I project seeks to address the unmet need for high-throughput, cost-effective research tools to model the metastasis of cancer cells. The proposed research objectives are to (1) discover cost-effective, commercially scalable methods allowing the production of aligned nanofibers in a 96-well plate format and (2) verify that the fiber alignment is ...

DESCRIPTION (provided by applicant): Preeclampsia, a hypertensive disorder of pregnancy, is a leading cause of maternal and neonatal morbidity and mortality around the world, responsible for approximately 76,000 maternal and 500,000 infant deaths per year.As a heterogeneous and poorly understood disorder, its pathogenesis and possible treatments are an area of active research. While the majority o ...

DESCRIPTION (provided by applicant): The broad objective of this proposal is to improve the clinical effectiveness of liver lesion biopsy by fusing respiratory-compensated PET with CT images in the CT suite. On CT imaging alone, localization of liver lesions can potentially be challenging, particularly in selected cases where differentiation of the tumor from adjacent liver parenchyma may be diffi ...

DESCRIPTION (provided by applicant): Validation of computing algorithms has been a challenging topic over the last few years. In fact, several international workshops in the medical imaging field started to involve the community through grand challenges . A grand challenge involves selecting driving biological/scientific problem and asking experts to submit their best results and methods to solve ...

DESCRIPTION (provided by applicant): Image-based evaluation of pathologies over time is complicated by variability in image acquisition and patient positioning, deformations due to respiratory and cardiac motion, and the clinical standard in radiology of comparing unaligned images. This application proposes a computational method for longitudinal image analysis that captures, illustrates and quant ...