Award Data

DESCRIPTION (provided by applicant): The goals of this proposal are to devise rapid serological tests that can replace the sputum smear test for the diagnosis of active TB and meets the WHO specifications to replace microscopy in resource-limited countries based on immunodominant peptides from three M. tb cell-wall proteins. Although direct smear microscopy is highly specific, the test is tedious, ...

DESCRIPTION (provided by applicant): Diagnosis of active tuberculosis (TB) in TB-endemic countries, where gt90% of the global TB cases occur, depends upon microscopic examination of sputum smears made directly from the specimen. While this test is highly specific, the test is tedious, time-consuming, requires multiple patient visits, and has limited and variable sensitivity WHO has repeatedly expr ...

ABSTRACT: Experimental testing of dynamic models has been performed for more than 50 years and a wealth of data exists for individual models. However, this data is often either restricted as proprietary or is not suitable for CSE tool validation as a result of incomplete model or test information. Mainstream Engineering proposes to design, fabricate, and test a scaled fighter for aeroelastic ...

The overall objective of the Phase I and Phase II proposed effort is to design and demonstrate the ability to develop a high-speed shock tolerant composite flywheel energy storage system (FESS) using a low cost manufacturing process. The Phase I tradeoff design studies will assess the FESS size, operating speeds and material requirements needed to achieve the energy density levels and charge/disch ...

DESCRIPTION (provided by applicant): The long term goal of this project is to develop and commercialize noninvasive equipment, called the sleep and respiratory track (SARTrak) system, for high throughput detection of sleep apnea in animals. The specific goal for the Phase I application is to design and evaluate a basic model of the SARTrak system with eight chambers (one chamber per animal), i.e. ...

DESCRIPTION (provided by applicant): Our goal is to develop an In Vitro Diagnostic Multivariate Assay (IVDMIA) to distinguish Essential Thrombocythemia (ET) from non-clonal reactive thrombocytosis (RT) etiologies. ET represents a distinct subtype of myeloproliferative disorders, thrombocytosis, characterized by increased proliferation of megakaryocytes and resultant elevated levels of circulating ...

In Phase I, ISSI will design and demonstrate a laser absorption-based sensor for time-resolved measurements of combustion fuel/product concentrations (H2O, CO, CO2 and fuel) and gas temperature within the detonation channels and nozzle exit-plane of a rotating detonation rocket engine (RDRE). The goal of this STTR is to develop a single sided sensor that plugs into the outer wall of the RDRE simil ...

Currently large capacity cryostats, capable of hosting experiments for many qubits, require expensive and hard to obtain liquid cryogens. A few small cryo-free systems exist but they are non-ideal for this use. An opportunity exists for a large scale, c

Currently large capacity cryostats, capable of hosting experiments for many qubits, require expensive and hard to obtain liquid cryogens. A few small cryo-free systems exist but they are non-ideal for this use. An opportunity exists for a large scale, c

Aerosolized pathogenssuch as Influenza virusescan spread rapidly and silently throughout a populationcausing severe outbreaks that can be difficult to controlEarly detection of these airborne pathogens is key to controlling outbreaksespecially among vulnerable populations such as in hospitalstreatment centers or nursing homesYet available methods are neither rapidnor portableCurrent methods rely h ...