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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 91 - 100 of 207712 results
  1. Recombinant expression of a biomaterial-targeting BMP-2 containing a peptide tag

    SBC: AFFINERGY, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): The emergence of biological therapeutics, including cells, peptides, and proteins, has allowed medical science to address a number of unmet clinical needs. Often these agents are extremely potent, specifically activating endogenous signaling cascades to promote well-characterized biochemical and physiological responses. For example, bone morphogenetic protein-2 ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  2. Development of a method to multiplex ChIP-SEQ and ChIP-chip experiments

    SBC: AFFOMIX, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): The immediate objective of our research is to generate a method that will enable researchers to multiplex Chromatin ImmunoPreciptation-Sequencing (ChIP-Seq) analysis in a single Next generation DNA sequencing run. In the to-be-developed method: i) a set of antibodies directed against specific DNA-binding proteins are uniquely bar-coded with a DNA 'ZipCode;' ii) ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput screening and identification of scFv antibodies against glycosyla

    SBC: AFFOMIX, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): The specific goal of this proposal is to develop a high-throughput method to identify scFv antibodies that recognize post-translationally modified proteins. We propose to complete a proof-of-concept for a new type of affinity screening process based on emulsion, secretion, and capture, which we term ESCape . In the proposed phage ESCape method, E. coli transfo ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. A bifunctional antibody screening system for both phage display and yeast two-hyb

    SBC: AFFOMIX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This is a proposal to establish a proof-of-principle for a vector system to isolate high-affinty antibodies through selective rounds in both yeast and Escherichia coli. Antibodies have quickly become extremely useful as therapeutic medicines to treat a wide-variety of disorders. We propose to develop a means of making the discovery of immunotherapeutics faster ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Water Toxicity Detection using Genetically Engineered Yeast

    SBC: AGAVE BIOSYSTEMS INC.            Topic: Army08174

    The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that remain viable for 6 months would be ideal. In Phase I, Agave BioSystems proposed to develop an accura ...

    SBIR Phase II 2010 Department of DefenseArmy
  6. Nucleic acid delivery of growth factors and heparan sulfate proteoglycans for enh

    SBC: International Medicine and Biomedical Research            Topic: NIAMS

    DESCRIPTION (provided by applicant): In chronic wounds, numerous factors contribute to the diminished healing. Wound healing constituents, including heparan sulfate proteoglycans and numerous growth factors, are essential to normal skin wound healing. Several key growth factors such as FGF, VEGF, and PDGF require heparan sulfate-like polymers as co- receptors or co-activators for growth factor act ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  7. SBIR Phase I:CyberCollage: A Collective Programming Environment for the Social Exploration of Computational Thinking through Games

    SBC: Agentsheets, Inc            Topic: EA

    This Small Business Innovation Research (SBIR) Phase I project seeks to build a system called CyberCollage as a cyberlearning tool to support computational thinking in STEM education at the middle school level. CyberCollage will enable the collective programming of educational games and computational science simulations through a social media approach that uniquely combines real-time synchronous ...

    SBIR Phase I 2010 National Science Foundation
  8. AlignShop: a comprehensive multiple sequence alignment editor and analysis tool

    SBC: AGILE GENOMICS, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Multiple sequence alignment (MSA) is a core element of bioinformatics, comparative genomics, phylogenetics, molecular, and structural biology. Several excellent software tools for MSA construction are heavily used by the biomedical community; however, essentially all automatically constructed MSAs require significant editing (error corrections) prior to their a ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  9. CMR Oxides Based Microbolometer Focal Plane Array with Reduced 1/f Noise

    SBC: AGILTRON, INC.            Topic: ARMY09T014

    We propose to realize a new class of microbolometer FPA technology with significantly reduced 1/f noise by replacing the sensing material (e.g. VOx) with colossal magnetoresistive (CMR) oxides. The program uniquely combines Agiltron's experience in novel IR imager development and leading academic research on CMR at Los Alamos National Lab (LANL). The LANL Team has developed breakthrough process ...

    STTR Phase II 2010 Department of DefenseArmy
  10. Compact Chemical Sensor for Measurement of Internal Dose of Environmental Agents

    SBC: AGILTRON, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Detection of exposure to environmental agents by measurement of internal dose of such agents or their metabolites, chemical or biological, requires rapid assessment and identification of exposure to both known and unknown threats. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of the exposure ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
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