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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 162567 results
  1. A Magnetized Electron Source for Ion Beam Cooling

    SBC: Xelera Research LLC            Topic: 23d

    Future electron-ion colliders for nuclear physics research require cooled ion beams to reach the desired luminosity for important experiments. Xelera Research LLC will design a magnetized electron injector and build a prototype source to be used to cool ion beams for future electron-ion colliders in the US.

    SBIR Phase II 2017 Department of Energy
  2. Establishing In Vivo Proof of Concept of Brown Adipogenesis Using Approved Drugs

    SBC: ENERGESIS PHARMACEUTICALS, INC.            Topic: 200

    DESCRIPTION provided by applicant Obesity has reached epidemic proportions in the U S and plays a major role in the development of type diabetes dyslipidemia and cardiovascular disease There remains a very significant need for better non surgical treatments While most weight loss agents rely on suppressing appetite to reduce caloric intake strategies that can safely enhance energy expe ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Integrated System for FFPE Sample Preparation

    SBC: COVARIS, INC.            Topic: NCI

    Summary Many samples taken from individuals and animals are stored by treating them with a chemical formalin and then encasing them in paraffin or wax these are called formalin fixed paraffin encased FFPE samples Usually this storage is very good for preserving them for observation under microscopes but it presents some problems in terms of analysis of their DNA Genetic analyses are impor ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Accurate protein folding software to predict ligand-induced conformational changes in G protein-coupled receptors

    SBC: DNASTAR, INC.            Topic: 100

    Abstract In humans and animals G protein coupled receptors GPCRs are embedded on cell surfaces and function as key regulators of physiological events by transmitting signals from extracellular stimulants across the cell membrane into the cell Impaired or abnormal GPCR function can result in disordered physiological processes causing a broad and diverse range of diseases For this reason GPCRs ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Wearable Patch Reader for Peripheral Artery Disease

    SBC: PROFUSA, INC.            Topic: NHLBI

    Abstract The goal of this Phase II SBIR is to convert Profusa s bulky cabled optical reader into a wearable flexible disposable bandage like format that conforms to the foot for continuous monitoring of tissue oxygen levels during revascularization and restenosis in patients with peripheral artery disease PAD is a manifestation of systemic atherosclerosis that affects million people i ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Optimizing NGF for Topical Treatment of Glaucoma

    SBC: HUMAN CELL COMPANY            Topic: N

    Glaucoma is one of the leading causes of blindness in the world This chronic and progressive optic neuropathy is characterized by loss of axons of the retinal ganglion cells RGC that constitute the optic nerve Reduction of elevated intraocular pressure the only modifiable causative factor slow the onset and progression of the disease yet no treatment is available to restore o ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Targeting Breast Cancer Metastasis with Id1

    SBC: ORGANIX, INC.            Topic: 102

    TBD

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Precision quality check of immunotherapeutics via single-cell cytokine mapping

    SBC: ISOPLEXIS, INC.            Topic: 102

    Adoptive transfer of autologous T cells engineered to express chimeric antigen receptors CARs has emerged as a promising immunotherapy for patients with hematologic malignancies such as CD CARs in leukemias and lymphomas However challenges remain in terms of manufacturing consistency and the functional profile of the CAR T cell product since infused cells as living drugs can be activat ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. SBIR Phase I: Novel Device for detecting changes in the esophageal lumen using single point ultrasonic transducers

    SBC: RefloDx LLC            Topic: BM

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will benefit nearly 6 million children per year who are suspected of having abnormal Gastroesophageal Reflux (GER) which can lead to a more serious condition with numerous complications referred to as Gastroesophageal Reflux Disease (GERD). Current detection paradigms include costly and invasi ...

    SBIR Phase I 2017 National Science Foundation
  10. SBIR Phase I: Novel Biomimetic Production of Broad-Spectrum Fungicide BioSurF-I

    SBC: Biomineral Systems LLC            Topic: BT

    The broader impact/commercial potential of this Small Business Innovation Research (SBIR) project will be the development of a biofungicide for application on organic farms as well as conventional farms and home and lawn care as an alternative to chemical fungicides. More than 70% of all major crop diseases are caused by fungi. Despite intensive disease control practices, these pathogens are still ...

    SBIR Phase I 2017 National Science Foundation

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