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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 164378 results
  1. Development of Cad Plating Replacement with Zinc Nickel on High Strength Steel Components

    SBC: (ES3) Engineering & Software System Solution, Inc.            Topic: AF071-320

    ABSTRACT: Landing gear components manufactured from high strength steel alloys require sacrificial protective coatings to perform safely in service. Cadmium has been the standard coating for such components for decades, but is a known carcinogen and has been targeted for elimination by the USAF. An experimental Zn-Ni coating was tested in Phase I as a replacement for cadmium. Results showed the ...

    SBIR Phase II 2016 Department of DefenseAir Force
  2. Development of a protein drug for pancreatic cancer treatment

    SBC: PRODA BIOTECH, LLC            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less than Currently there is no effective treatment for advanced disease One major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal response Evidence suggests that cancer associated pancreatic stellate cells CAPaSC produce the stromal collagen The ECM laid down by CAPaSC is c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel therapy for Fragile X syndrome

    SBC: EPIGEN BIOSCIENCES, INC.            Topic: 101

    PROJECT SUMMARY Fragile X syndrome FXS is the most common inheritable form of cognitive impairment and the leading known genetic cause of autism FXS is caused by the loss of expression of the fragile X mental retardation protein FMRP A major challenge for FXS research is to develop treatment strategies that improve the intellectual capabilities of patients Dysregulated protein synthesis is ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A user-friendly scalable microfluidic platform for enhanced neuron-cell culture

    SBC: XONA MICROFLUIDICS, LLC            Topic: 101

    DESCRIPTION provided by applicant Neuron cell culture is widely used for studies in basic research drug discovery and toxicity testing Traditional neuron cell culture approaches result in random growth of processes which prevent the study of their unique polarized morphology Our goal is to provide robust user friendly and cost effective culture platforms to manipulate and access neurons a ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Breast Cancer Locator

    SBC: CAIRNSURGICAL, INC.            Topic: 101

    PROJECT SUMMARY ABSTRACT CairnSurgical LLC a Dartmouth spin off company will optimize and test multi site clinical feasibility of a new image guided intervention device the Breast Cancer Locator BCL in breast conserving surgery BCS to i eliminate wire localization a moderately effective somewhat costly and certainly inconvenient procedure for patients and surgeons and concomitantl ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Exosomal Drug Delivery

    SBC: 3P BIOTECHNOLOGIES, INC.            Topic: 102

    Technical Abstract As with many chemotherapeutic drugs taxanes exhibit poor oral bioavailability hence they are administered intravenously i v This regimen results in significant toxicities due to both the high drug dose and vehicle Cremophore ELR used Attempts made to develop an oral chemotherapeutic using liposomes and polymeric nanoparticles as carriers have not made it to the cli ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A high brightness microstructured anode X-ray source for clinical phase contrast imaging

    SBC: SIGRAY, INC.            Topic: NIBIB

    X ray phase contrast imaging XPCI is widely regarded as one of the most exciting techniques to have emerged in x ray physics and has potential to significantly change the face of biomedical imaging XPCI which is based on the refraction of X rays rather than their absorption can provide up to times greater contrast in soft tissues than absorption contrast which is the current method emp ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Inhibitors of PSMB7 and PSMB10 for the Treatment of Multiple Myeloma

    SBC: INHIPROT, LLC            Topic: 103

    Multiple myeloma is incurable hematologic malignancy with an expected median survival of years The proteasome inhibitors bortezomib carfilzomib and the recently approved ixazomib are a mainstay of current myeloma treatment Despite an initial response rate approaching to proteasome inhibitor containing combinations all patients relapse and eventually become resistant to any treatments ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Drug-eluting Brachytherapy Implants for Chemo-radiation Therapy

    SBC: THERANANO, LLC            Topic: 102

    Prostate cancer PCa is the second leading cause of cancer death in American men with deaths and new cases estimated in the US in Radiation therapy is one of the standard therapies for high and intermediate risk patients and is a non surgical therapy option for low risk patients A combined chemo radiation therapy CRT approach has been shown in several trials to improve s ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Isolation and characterization of a primary breast epithelium transforming agent

    SBC: SKINAXIS, LLC            Topic: 102

    Abstract Breast cancer BC is the most common cancer among women Viruses have long been suspected as a cause of breast cancer However despite the identification of virions in human BC cells and human milk and numerous studies that suggest possible connection between breast cancer and Epstein Barr virus EBV mouse mammary tumor virus MMTV and human papilloma virus HPV the tumorigenic po ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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