Ultrasensitive In Vivo Bone Lead Spectometer

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 22209
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1993
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
240 Dr. Martin L. King Bouleva, Newark, NJ, 07102
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Bonnie Schnitta
 (516) 324-1300
Business Contact
Phone: () -
Research Institution
The aim is to develop a highly accurate non-invasive determination of lead in bone by means of a sophisticated multistage signal processing technique, which is driven by case-based reasoning and a hybrid neural network. The validity and processing gain of the method shall be proven on Atlantex ln-Vivo Lead Spectrometer (INVILS) data. The objective is to allow INVILS to quantify lead spectral peaks more accurately with less data. This will reduce x-ray exposure and allow accurate measurement at low lead levels where prior systems were unable to measure. The signal processing algorithm will be composed of four stages: a noise filter, a peak locator, a neural network peak identifier, and a case-based expert system for peak ratios enhancement. The research will also prototype a user friendly window-driven interface. This will enable future versions of INVILS to be employed at different locations such as hospitals, clinics, factories, etc. The device will supplement the use of blood-lead tests and will largely replace the use of provocative chelation testing. INVILS will be used for screening children at high risk of lead poisoning, industrially exposed workers, and for certain classes of the general population, such as those suffering from renal disease.

* Information listed above is at the time of submission. *

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