SILICON DETERMINATION FOR NUTRITION WITH RESONANCE IONIZATION MASS SPECTROMETRY

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$150,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
6880
Agency Tracking Number:
6880
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
114 Ridgeway Cntr, Oak Ridge, TN, 37830
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Larry J Moore
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
SILICON MAY HAVE METABOLIC ROLES IN ATHEROSCLEROTIC DISORDERS, CONNECTIVE TISSUE AND BONE FORMATION, MORPHOGENESIS IN PRIMITIVE CELLS AND THE AGING PROCESS. HOWEVER, LITTLE IS KNOWN ABOUT THE ROLE OF SILICON IN HUMAN NUTRITION AND METABOLISM. THE ABSENCE OF A RELIABLE ANALYTICAL TOOL FOR TRACE AND ULTRA-TRACE ELEMENTAL AND ISOTOPIC DETERMINATIONS HAS BEEN A MAJOR IMPEDIMENT TO THE ACQUISITION OF KNOWLEDGE. RECENT DEVELOPMENTS IN LASER RESONANCE IONIZATION HAVE PRODUCED A UNIQUE ANALYTICAL TOOL - RESONANCE IONIZATION MASS SPECTROMETRY (RIMS) - TO PERMIT THE MICRODETERMINATION OF SILICON IN BIOLOGICAL TISSUES AND FLUIDS. RIMS IS PROPOSED TO IONIZE SILICON SENSITIVELY AND SELECTIVELY IN THE PRESENCE OF OTHER ELEMENTS AND IMPURITIES, FOLLOWED BY QUANTITATION WITH ISOTOPE DILUTION AS AN INTERNAL STANDARD. THE TECHNICAL OBJECTIVES FOR PHASE I ARE: 1) TO DEVELOP AND DEMONSTRATE A PROCESS TO ATOMIZE ULTRA-TRACE QUANTITIES OF SILICON; 2) TO DEVELOP AND APPLY A RESONANCE IONIZATION SCHEME FOR THE SELECTIVE AND SENSITIVE IONIZATION OF SILICON IN THE PRESENCE OF OTHER ELEMENTS AND IMPURITIES; 3) TO DETERMINE, WITH MINIMUM CHEMICAL PRETREATMENT, ULTRA-TRACE QUANTITIES OF SILICON IN SELECTED BIOLOGICAL SAMPLES. PHASE I RESEARCH WILL PROVIDE THE SCIENTIFIC AND TECHNOLOGICAL BRIDGE TO PERMIT THE APPLICATION OF SILICON DETERMINATIONS TO SPECIFIC PROBLEMS IN NUTRITION AND METABOLISM. THE TECHNOLOGY WILL BE APPLICABLE TO THE DETERMINATION OF NUTRITIONAL REQUIREMENTS, PARTICULARLY FOR THE AGED, AND POTENTIALLY TO THE DIAGNOSIS AND SCREENING OF ATHEROSCLEROTIC DISORDERS. OTHER APPLICATIONS WOULD BE FOR RELIABLE SILICON DETERMINATIONS IN OTHER NATURAL MATERIALS, STEELS AND RELATED HIGH-TECH MATERIALS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government