AN ATOM CLUSTER ION DESORPTION SOURCE

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1988
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
8114
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Atom Sciences Inc
114 Ridgeway Ctr, Oak Ridge, TN, 37830
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE NEED TO CHARACTERIZE COMPLEX ORGANIC COMPOUNDS FOR BIOTECHNOLOGY APPLICATIONS, SUCH AS PROTEIN SEQUENCING, HAS PLACED STRINGENT REQUIREMENTS ON THE DEVELOPMENT OF CHARACTERIZATION TOOLS. RECENT DEVELOPMENTS IN CLUSTER ION FORMATION AND ION BOMBARDMENT DESORPTION THEORY SUGGEST THATCLUSTER ION BOMBARDMENT OF COMPLEX MOLECULES MAY PROVIDE A MECHANISM TO CHARACTERIZE COMPLEX SPECIES AND SIGNIFICANTLY IMPROVE THE ABILITY TO SEQUENCE PROTEINS. THE SPECIFIC AIMSARE TO: 1) DEVELOP A SUPERSONIC NOZZLE TO PRODUCE HOMONUCLEAR ATOM CLUSTER DENSITIES UP TO 10(15) CM(-3); 2) MODIFY A TIME-OF-FLIGHT ION EXTRACTION SOURCE TO ACCOMMODATE THE LASER IONIZATION OF ATOM CLUSTERS; 3) EVALUATE THE CLUSTER ION DENSITIES AND SIZE DISTRIBUTIONS USING A MODIFIED TIME-OF-FLIGHT MASS SPECTROMETER; 4) DEMONSTRATE THE FEASIBILITY OF DESORBING HIGH MOLECULAR WEIGHT ORGANIC MOLECULES. THE SUCCESSFUL COMPLETION OF THESE AIMS IS EXPECTED TO RESULT IN A VERSATILE CLUSTER ION SOURCE TO DESORB NEUTRAL AND IONIZED HIGH MOLECULAR WEITHT ORGANIC COMPOUNDS, SUCH AS PEPTIDES AND PEPTIDE CHAINS. THE MOLECULES OR MOLECULAR IONS MAY BE FURTHER CHARACTERIZED USING EXISTING MASS SPECTROMETRIC AND LASER TECHNOLOGY. COMMERCIAL POTENTIAL INCLUDES THE DEVELOPMENT FOR SALE OF A SIMPLIFIED ATOM CLUSTER ION DESORPTION SOURCE (ACIDS) AND THE DEVELOPMENT OF AN APPLICATIONS MARKET FOR ANALYTICAL CHARACTERIZATION SERVICES FOR PROTEIN SEQUENCING.

* information listed above is at the time of submission.

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