SUBPICOSECOND DESORPTION AND MASS ANALYSIS OF LARGE MOLECULES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
7377
Agency Tracking Number:
7377
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
114 Ridgeway Center, Oak Ridge, TN, 37830
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
LARRY J MOORE
(615) 483-1113
Business Contact:
() -
Research Institute:
n/a
Abstract
EMERGING HEALTH AND MEDICAL RESEARCH PROBLEMS ARE PLACING STRINGENT REQUIREMENTS ON THE ABILITY TO CHARACTERIZE LABILEAND HIGH-MOLECULAR-WEIGHT ORGANIC COMPOUNDS. IN BIOTECHNOLOGY, FOR EXAMPLE, INTERMEDIATE SYNTHESIS PRODUCTS MUST BE IDENTIFIED. RECENT ION BOMBARDMENT DESORPTION MODELS SUGGEST THAT HIGHEST-MOLECULAR-WEIGHT COMPOUNDS WOULDDESORB MOST EFFICIENTLY THROUGH RAPID, MULTIPLE EXCITATIONS NEAR THE MOLECULAR ATTACHMENT SITE. RESONANCE IONIZATION SPECTROSCOPY HAS THE POTENTIAL TO DELIVER SPATIALLY CONSTRAINED PRIMARY ION BUNDLES ON TARGET IN THE PICOSECOND RANGE. THE SUCCESSIVE ION ARRIVAL-TIME INTERVALS FOR THIS SOURCE ARE COMMENSURATE WITH SUBPICOSECOND TIMES THEORETICALLY PREDICTED FOR MOLECULAR MOTION AND ENERGY TRANSFER TO THE ATTACHMENT SITE. THE SPECIFIC AIMS OF THIS PROPOSAL ARE TO: (1) MODIFY A THERMAL ATOMIZATION SOURCE AND ION-EXTRACTION LENS FOR A PRIMARY RESONANCE-IONIZATION BOMBARDMENT SOURCE; (2) MODIFY AN EXISTING TIME-OF-FLIGHT MASS SPECTROMETER FOR HIGHER RESOLUTION; (3) EVALUATE THE TEMPORAL WIDTH OF THE PRIMARY ION PULSE; AND (4) INVESTIGATE THE FEASIBILITY OF EFFICIENT DESORPTION OF VERY HIGH-MOLECULAR-WEIGHT SPECIES. THE POTENTIAL MULTIPLE EXCITATION EFFICIENCY AND TEMPORAL RESOLUTION OF THE PROPOSED SOURCE WOULD SIMULTANEOUSLY PROVIDE THE BASIS FOR DESORPTION OF VERY HIGH-MOLECULAR-WEIGHT MOLECULES AND FOR AN ULTRAHIGH-RESOLUTION, TIME-OF-FLIGHT MASS SPECTROMETER.

* information listed above is at the time of submission.

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