IMAGING OF BORON IN TISSUE AT CELLULAR LEVEL FOR BNCT

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$49,927.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
16413
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Atom Sciences, Inc
114 Ridgeway Center, Oak Ridge, TN, 37830
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Arlinghaus, Heinrich F
Principal Investigator
(615) 483-1113
Business Contact:
1 R43 CA54627-01
() -
Research Institution:
n/a
Abstract
BORON NEUTRON CAPTURE THERAPY (BNCT) IS CONDUCTED BY LOADING BORON BIOCHEMICALLY INTO A TUMOR AND IRRADIATING WITH THERMAL NEUTRONS. SINCE THE RANGES OF THE ALPHA PARTICLES AND LITHIUM IONS THAT RESULT FROM THE CAPTURE ARE VERY SHORT (MUM), THE CLINICAL EFFICACY IS ONLY GUARANTEED IF THIS BORON IS IN A SENSITIVE AREA OF THE TUMOR CELL. SEVERAL TECHNIQUES SUCH AS ALPHA TRACK-ETCH AND SECONDARY ION MASS SPECTROMETRY (SIMS) HAVE BEEN USED TO LOCALIZE BORON IN INDIVIDUAL CELLS, BUT NEITHER TECHNIQUE HAS BEEN TOTALLY SUCCESSFUL IN QUANTITATIVE LOCALIZATION. RESONANCE IONIZATION SPECTROSCOPY (RIS), A NEW ULTRA-TRACE ELEMENT ANALYSIS TECHNIQUE, UTILIZES PRECISELY TUNED LASERS TO EFFICIENTLY IONIZE A CHOSEN ELEMENT WITHOUT INTERFERENCE FROM THE OVERWHELMING LARGE BACKGROUND OF OTHER CONSTITUENTS IN THE SAMPLE. RIS, WHEN COMBINED WITH ION SPUTTERING LEADS TO A NEW ANALYTICAL TECHNIQUE - SPUTTER INITIATED RESONANCE IONIZATION SPECTROSCOPY (SIRIS). IT HAS ALMOST ALL OF THE ADVANTAGES OF SIMS, AND SURPASSES IT IN THE FOLLOWING SIMS SHORTCOMINGS: EFFICIENCY, MATRIX DEPENDENCE, ISOBARIC AND MOLECULAR INTERFERENCES, AND SENSITIVITY. WE WILL USE SIRIS TO LOCALIZE AND QUANTITATE THE BORON CONCENTRATION IN CELLS AT THE PARTS PER MILLION (PPM), OR SUB-PPM LEVEL WITH RESOLUTION AT MICROMETER, OR SMALLER DIMENSIONS.

* information listed above is at the time of submission.

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