ULTRA SENSITIVE ANALYSIS FOR PT BY RIS IN TUMOR THERAPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1991
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
16442
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Atom Sciences, Inc
114 Ridgeway Center, Oak Ridge, TN, 37830
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Taylor, Ellison H
Principal Investigator
(615) 483-1113
Business Contact:
1 R43 CA55459-01
() -
Research Institution:
n/a
Abstract
THE PLATINUM COMPOUND CISPLATIN IS WIDELY USED IN THE TREATMENT OF SOLID TUMORS. PRACTICAL PROBLEMS OF TOXICITY, DECREASING EFFICACY OVER TIME AND OTHER S ARISE, AND CAN BE ATTACKED MOST EFFECTIVELY THROUGH A BETTER KNOWLEDGE OF THE VARIOUS MECHANISMS INVOLVED, REQUIRING THE ABILITY TO MEASURE THE ACTIVE MATERIAL AT SITES OF INTEREST AND AT THE CONCENTRATION LEVELS EXISTING THERE. PRESENT ANALYTICAL TECHNIQUES ARE NOT SENSITIVE ENOUGH TO MONITOR THE ENTRANCE OF CISPLATIN INTO CELLS AND NUCLEI USING THE LIMITED AMOUNT OF BLOOD THAT CAN BE DRAWN IN SERIAL SAMPLES FROM PATIENTS. INTER-PATIENT STUDIES, FOR WHICH SMALL VARIATIONS IN VERY LOW LEVELS WOULD HAVE TO BE MEASURED, WOULD BE VERY DESIRABLE. AN EMERGING ANALYTICAL TECHNIQUE, RESONANCE IONIZATION SPECTROSCOPY (RIS), HAS DEMONSTRATED EXTREMELY HIGH SELECTIVITY AND SENSITIVITY IN ELEMENTAL ANALYSIS. RIS UTILIZES LASERS TUNED TO STATES UNIQUE TO THE DESIRED ELEMENT, THEREBY ACHIEVING EFFICIENT IONIZATION OF THE ANALYTE WITH ESSENTIALLY NO BACKGROUND. THESE CHARACTERISTICS ARE EXTENDABLE TO PLATINUM, AND WOULD PROVIDE A SOLUTION TO THE AIMS DESCRIBED ABOVE. INSTRUMENTAL AND CHEMICAL DEVELOPMENTS WILL APPLY THIS METHOD SPECIFICALLY TO PLATINUM IN BIOLOGICAL MATRICES. SAMPLE ATOMIZATION OPTIONS WILL BE INVESTIGATED TOGETHER WITH QUANTITATION OPTIONS, INCLUDING ISOTOPE DILUTION, TO MINIMIZE COMPLEXITY AND ASSURE RELIABILITY.

* information listed above is at the time of submission.

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