Inexpensive Genetic Detection of Infectious Organisms

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44AI049596-02A1
Agency Tracking Number: AI049596
Amount: $0.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (865) 483-1113
Business Contact
Phone: (865) 483-1113
Research Institution
DESCRIPTION (provided by applicant): The aim of the research project is to develop a very inexpensive and rapid capacitance measurement technique that can be used as a diagnostic test to identify specific infectious organisms, their resistance to antimicrobial drugs, and their pathogenicity in a clinical setting. The goal is to make the cost so low that managed health organizations would encourage its use to identify pathogens and their resistance to antibiotics, thus greatly reducing the prescription of antibiotics in cases where they are ineffective, and consequently reducing one source of development of antimicrobial resistant strains of bacteria. The proposed diagnostic is based upon capacitance detection of DNA hybridization to probes on an array. In Phase I, we have demonstrated the technique works using both oligonucleotide and peptide nucleic acid (PNA) probes on coated gold insulators. We have also systematically explored the probe attachment and hybridization chemistry and their relationship to the stability of capacitance measurements on the array. In Phase II, we will continue to improve the chemistry and measurement hardware. We will also develop prototype arrays to detect some of the common pathogens encountered in a clinical setting.

* Information listed above is at the time of submission. *

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