On Orbit Immuno-Based, Label-Free, White Blood Cell Counting System with MicroElectroMechanical Sensor (MEMS) Technology (OILWBCS-MEMS)

Award Information
Agency:
National Aeronautics and Space Administration
Amount:
$99,948.00
Program:
SBIR
Contract:
NNX09CE44P
Solitcitation Year:
2008
Solicitation Number:
N/A
Branch:
N/A
Award Year:
2009
Phase:
Phase I
Agency Tracking Number:
084136
Solicitation Topic Code:
X14.02
Small Business Information
Aurora Flight Sciences Corporation
9950 Wakeman Drive, Manassas, VA, 20110-2702
Hubzone Owned:
N
Woman Owned:
N
Socially and Economically Disadvantaged:
N
Duns:
604717165
Principal Investigator
 Liping Sun
 Principal Investigator
 (617) 500-0279
 lsun@aurora.aero
Business Contact
 Scott Hart
Title: Financial Analyst
Phone: (617) 500-0536
Email: shart@aurora.aero
Research Institution
N/A
Abstract
Aurora Flight Sciences Corporation and our partner, Draper Laboratory, propose to develop an on orbit immuno-based, label-free, white blood cell counting system for simultaneous counting of peripheral blood cell subpopulations, including total white blood cells, the five white blood cell differential subgroups, and various lymphocyte subtypes, such as CD4 and CD8 positive cells, using Draper's MicroElectroMechanical Sensor (MEMS) based microfabricated arrayable Adhesive Stress Electrostatic Sensor (ASES) technology. The proposed ASES sensor uses a capacitance read-out method to electronically measure the sensor membrane displacement due to the surface stress caused by molecular binding, (e.g., antibody-antigen binding). Antibodies specific to the white blood cell surface protein markers (antigens) are precoated on the ASES sensor membrane to recognize the specific white blood cell types with inherently high specificity and sensitivity. Our proposed cell counting system can meet NASA's requirements for a microgravity compatible, miniaturized, light weight peripheral blood cell counting instrument capable of on-orbit cell counting, without high energy lasers, requiring minimal sample volume or exogenous (sheath) fluid to operate, and generating minimal biohazardous waste. This ASES blood cell counting system, once developed, can stand alone for white blood cell differential and subtype count, or become a complimentary instrument to others available on-orbit.

* information listed above is at the time of submission.

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