Neuromonitoring of Traumatic Brain/blast Injury

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-10-C-0061
Agency Tracking Number: O093-H06-3094
Amount: $99,973.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2009
Solicitation Topic Code: OSD09-H06
Solicitation Number: 2009.3
Small Business Information
2237 Faraday Ave, Suite 100, Carlsbad, CA, 92008
DUNS: 969842715
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Djordje Popovic
 Director of Research
 (760) 720-0099
Business Contact
 Christine Berka
Title: Chief Executive Officer
Phone: (760) 720-0099
Research Institution
It is well known that the brain is the organ most sensitive to ischemia/hypoxia. Noninvasive continuous monitoring of cerebral blood flow autoregulation, cerebrovascular reactivity and related phenomena such as cerebral vasospams in combat casualties could guide clinicians/medics in adjusting the strategy of resuscitation and acute care, and therefore contribute to a substantially improved survival and functional outcome. We propose to develop a small, light-weight, battery powered and hand-portable 3-channel monitor that combines electro- and rheoencephalography (EEG and REG). While REG detects changes in cerebral vascular bed, EEG can be used to detect post-traumatic non-convulsive seizures or reversible breakdown of the synaptic transmission. The monitor consists of a smaller (2 x 2 x 0.5 in) wearable unit for data acquisition and a larger (7 x 5 x 0.8) unit for visualization and storage of data. The units communicate to each other wirelessly, via a Bluetooth link, or through a cable. The larger unit processes the incoming data in real time, and warns clinicians (via an audio alarm) of a deterioration of the patient''s condition. The bigger unit can connect to a LAN or the internet so that the REG/EEG data can be downloaded and analyzed offline by clinicians.

* Information listed above is at the time of submission. *

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