ENVIRONMENT

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
3718
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Automated Diagnostic Systems
2422 S Walter Reed Dr, Arlington, VA, 22206
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DR JOHN W COMBS
(301) 338-1653
Business Contact:
() -
Research Institution:
n/a
Abstract
PHASE I OF THIS PROJECT WILL DEMONSTRATE THE FEASIBILITY OF DETECTION AND CLASSIFICATION OF PATHOGENIC MICROBES BY A FULLY AUTOMATED SYSTEM WHICH WILL OPERATE IN A WIDE RANGE OF MILITARY, SPACE, AND CIVILIAN ENVIRONMENTS. BECAUSE OF ITS MILITARY RELEVANCE, PREVALENCE, MORBIDITY, MORTALITY, AND DIAGNOSTIC AND THERAPEUTIC COMPLEXITY, MALARIA WILL BE STUDIED AS A PROTOTYPIC DISEASE. IN PHASE I, THE DETAILED SPECTRAL CHARACTERISTICS OF THE INTERNAL-CONSTITUENTS OF UNSTAINED AND CYTOCHEMICALLY STAINED MALARIA PARASITES AND INFECTED HOST ERYTHROCYTES WILL BE DETERMINED. FLUORESCENT ANTIBODIES DIRECTED AGAINST ANTIGENS OF THE PARASITES WILL BE TESTED FOR SUITABILITY AS QUANTITATIVE IMMUNOFLUORESCENT PROBES. DIAGNOSTIC CLUES FOR DETECTION AND SPECIATION OF MALARIA PARASITES FOUND IN THESE PILOT STUDIES WILL BE EVALUATED FOR INCORPORATION INTO A RELIABLE, LOW-COST, DISPOSABLE DEVICE USEFUL IN THE MILITARY MEDICAL CONTEXT RANGING FROM THE BASE HOSPITAL TO THE BATTLE ZONE. THE RESULTS WILL ALSO GUIDE THE EXPLORATION OF AUTOMATED DETECTION AND CLASSIFICATION OF OTHER PATHOGENS OF MILITARY IMPORTANCE.

* information listed above is at the time of submission.

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